Virus-like particles as a modular system for novel vaccines

被引：48

作者：

Lechner, F ^{[1
]}

Jegerlehner, A ^{[1
]}

Tissot, AC ^{[1
]}

Maurer, P ^{[1
]}

Sebbel, P ^{[1
]}

Renner, WA ^{[1
]}

Jennings, GT ^{[1
]}

Bachmann, MF ^{[1
]}

机构：

[1] Cytos Biotechnol AG, CH-8952 Schlieren, Switzerland

来源：

INTERVIROLOGY | 2002年 / 45卷 / 4-6期

关键词：

virus-like particles; vaccine; antibody response; self antigen; adjuvant; tolerance; therapy;

D O I：

10.1159/000067912

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Induction of protective immune responses with recombinant antigens is a major challenge for the vaccine industry. Here we present a molecular assembly system that renders antigens of choice highly repetitive. Using this method, efficient antibody responses may be induced in the absence of adjuvants resulting in protection from viral infection and allergic reactions. Copyright (C) 2003 S. Karger AG, Basel.

引用

页码：212 / 217

页数：6

共 24 条

[1] Bachmann Martin F., 2001, Drug Discovery Today, V6, P566, DOI 10.1016/S1359-6446(01)01811-6
[2] THE INFLUENCE OF ANTIGEN ORGANIZATION ON B-CELL RESPONSIVENESS
BACHMANN, MF
ROHRER, UH
KUNDIG, TM
BURKI, K
HENGARTNER, H
ZINKERNAGEL, RM
[J]. SCIENCE, 1993, 262 (5138) : 1448 - 1451
[3] Neutralizing antiviral B cell responses
Bachmann, MF
Zinkernagel, RM
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 : 235 - 270
[4] Recombinant Norwalk virus-like particles given orally to volunteers: Phase I study
Ball, JM
Graham, DY
Opekun, AR
Gilger, MA
Guerrero, RA
Estes, MK
[J]. GASTROENTEROLOGY, 1999, 117 (01) : 40 - 48
[5] Nasal immunization of mice with human papillomavirus type 16 virus-like particles elicits neutralizing antibodies in mucosal secretions
Balmelli, C
Roden, R
Potts, A
Schiller, J
De Grandi, P
Nardelli-Haefliger, D
[J]. JOURNAL OF VIROLOGY, 1998, 72 (10) : 8220 - 8229
[6] Therapeutic vaccination with p24-VLP and zidovudine augments HIV-specific cytotoxic T lymphocyte activity in asymptomatic HIV-infected individuals
Benson, EM
Clarkson, J
Law, M
Marshall, P
Kelleher, AD
Smith, DE
Patou, G
Stewart, GJ
Cooper, DA
Ffrench, RA
[J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 1999, 15 (02) : 105 - 113
[7] Induction of autoantibodies to mouse CCR5 with recombinant papillomavirus particles
Chackerian, B
Lowy, DR
Schiller, JT
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (05) : 2373 - 2378
[8] Conjugation of a self-antigen to papillomavirus-like particles allows for efficient induction of protective autoantibodies
Chackerian, B
Lowy, DR
Schiller, JT
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2001, 108 (03) : 415 - 423
[9] Antibody humanization: a case of the 'Emperor's new clothes'?
Clark, M
[J]. IMMUNOLOGY TODAY, 2000, 21 (08): : 397 - 402
[10] 3-DIMENSIONAL STRUCTURE OF HEPATITIS-B VIRUS CORE PARTICLES DETERMINED BY ELECTRON CRYOMICROSCOPY
CROWTHER, RA
KISELEV, NA
BOTTCHER, B
BERRIMAN, JA
BORISOVA, GP
OSE, V
PUMPENS, P
[J]. CELL, 1994, 77 (06) : 943 - 950

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