Relationship between Resistance to Ethambutol and Rifampin and Clinical Outcomes in Mycobacterium avium Complex Pulmonary Disease

被引：9

作者：

Moon, Seong Mi ^{[1
]}

Kim, Su-Young ^{[2
]}

Kim, Dae Hun ^{[2
]}

Huh, Hee Jae ^{[3
]}

Lee, Nam Yong ^{[3
]}

Jhun, Byung Woo ^{[2
]}

机构：

[1] Sungkyunkwan Univ, Samsung Changwon Hosp, Dept Med, Div Pulm & Crit Care Med,Sch Med, Chang Won, South Korea

[2] Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Div Pulm & Crit Care Med,Sch Med, Seoul, South Korea

[3] Sungkyunkwan Univ, Samsung Med Ctr, Dept Lab Med & Genet, Sch Med, Seoul, South Korea

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2022年 / 66卷 / 04期

关键词：

Mycobacterium avium complex; ethambutol; rifampin; MIC; outcome; MACROLIDE RESISTANCE; RPOB GENE; TUBERCULOSIS; INFECTION; MUTATIONS; EPIDEMIOLOGY; EMERGENCE; THERAPY;

D O I：

10.1128/aac.02027-21

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We evaluated the associations between the in vitro activities of ethambutol and rifampin and clinical outcomes of Mycobacterium avium complex (MAC) pulmonary disease (PD). Among 158 patients with MAC-PD, there was no relationship between high MICs for ethambutol and/or rifampin and treatment failure for MAC-PD. Ethambutol and rifampin resistance was common among MAC isolates (rates of 87% and 59%, respectively), but mutations in embB, rpoB, and rpoC were rare, with detection in only 4% of the drug-resistant MAC isolates.

引用

页数：5

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