The effect of diet type on the plasma disposition of triclabendazole in goats

The effect of two different diet types (concentrate feed+hay and grazing) on the pharmacokinetic profiles of triclabendazole following oral administration in goats was investigated. A total of 12 goats were randomly allocated into two groups which were either indoor and fed concentrate+hay ration (housed group) or were grazing on pasture (grazing group). Triclabendazole was administered orally to animals in two groups at 10 mg/kg bodyweight. Blood samples were collected from 1 h to 192 h post-treatment and analyzed by high performance liquid chromatography (HPLC). Feeding with different diets significantly effected the plasma disposition of triclabendazole sulphoxide. Maximum plasma concentration (C-max:13.22 +/- 12.81 mu g/ml), time to reach maximum plasma concentration (t(max):18.4 +/- 2.19 h), area under the curve (AUC:613 +/- 137 mu g h/ml), half-life (t(1/2): 24.77 +/- 1.94 h) and mean resident time (MRT:40.22 +/- 4.36 h) of triclabendazole sulphoxide in housed group were significantly different from those of grazing group (C-max: 10.17 +/- 1.51 mu g/ml, t(max):14.0 +/- 2.19 h., AUC: 406 +/- 98 mu g h/ml), t(1/2): 16.16 +/- 1.17 h and MRT: 34.48 +/- 4.40 h). It is concluded that anthelmintically more active sulphoxide metabolite has higher plasma concentration when triclabendazole is administered to goats fed with concentrate feed+hay compared to grazing goats. (C) 2006 Elsevier Ltd. All rights reserved.