The clinical characteristics of patients with IgG4-related disease with infiltration of the labial salivary gland by IgG4-positive cells

被引:15
作者
Abe, Ayumi [1 ]
Takano, Kenichi [1 ]
Seki, Nobuhiko [1 ]
Jitsukawa, Sumito [1 ]
Yamamoto, Motohisa [2 ]
Takahashi, Hiroki [2 ]
Himi, Tetsuo [1 ]
机构
[1] Sapporo Med Univ, Sch Med, Dept Otolaryngol, Sapporo, Hokkaido 0608543, Japan
[2] Sapporo Med Univ, Sch Med, Dept Gastroenterol Rheumatol & Clin Immunol, Sapporo, Hokkaido 0608543, Japan
关键词
IgG4; Labial salivary gland; Mikulicz's disease; PET; sIL-2R; SCLEROSING PANCREATITIS; INTERLEUKIN-2; RECEPTOR; MIKULICZS-DISEASE;
D O I
10.3109/14397595.2014.891964
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives. Mikulicz's disease (MD) is an immunoglobulin (Ig) G4-related disease with systemic symptoms. Submandibular gland (SMG) biopsy is recommended for patients with possible IgG4-related MD for accurate differential diagnosis; however, it is difficult for certain patients to undergo this procedure. In contrast, labial salivary gland (LSG) biopsy is more convenient. Here we present an analysis of patients with IgG4-related MD whose LSG specimens were infiltrated with abundant IgG4-positive plasma cells. Methods. Sixteen patients diagnosed with IgG4-related MD underwent simultaneous SMG and LSG biopsies. We evaluated patients' serological and F-18-fluoro-2-deoxyglucose-positron emission tomography/computed tomography (F-18-FDG-PET/CT) and grouped them as LSG + (LSG specimens with >40% IgG4-positive plasma cells/IgG-positive plasma cells, 11 patients) or LSG - (LSG specimens with >40% IgG4-positive plasma cells/IgG-positive plasma cells, 6 patients). Results. There were not significant differences in serum IgG and IgG4 levels between the two groups; however, serum concentrations of soluble interleuikin-2 receptor (sIL-2R) were significantly higher in the LSG + group. All patients with increased F-18-FDG uptake in their parotid glands were a part of the LSG + group. Conclusions. When a SMG biopsy is not possible, the serum concentration of sIL-2R and F-18-FDGPET/ CT findings may predict whether LSG biopsy will facilitate the diagnosis of IgG4-related MD.
引用
收藏
页码:949 / 952
页数:4
相关论文
共 20 条
[1]   SERUM LEVELS OF INTERLEUKIN-2 RECEPTOR AND ACTIVITY OF RHEUMATIC DISEASES CHARACTERIZED BY IMMUNE-SYSTEM ACTIVATION [J].
CAMPEN, DH ;
HORWITZ, DA ;
QUISMORIO, FP ;
EHRESMANN, GR ;
MARTIN, WJ .
ARTHRITIS AND RHEUMATISM, 1988, 31 (11) :1358-1364
[2]   INCREASED LEVELS OF SOLUBLE INTERLEUKIN-2 RECEPTOR IN NON-HODGKINS LYMPHOMAS - RELATIONSHIP WITH CLINICAL, HISTOLOGIC, AND PHENOTYPIC FEATURES [J].
CHILOSI, M ;
SEMENZATO, G ;
VINANTE, F ;
MENESTRINA, F ;
PIAZZOLA, E ;
FOCCHIATTI, V ;
SABBIONI, R ;
ZANOTTI, R ;
PIZZOLO, G .
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1989, 92 (02) :186-191
[3]   Consensus statement on the pathology of IgG4-related disease [J].
Deshpande, Vikram ;
Zen, Yoh ;
Chan, John K. ;
Yi, Eunhee E. ;
Sato, Yasuharu ;
Yoshino, Tadashi ;
Kloeppel, Guenter ;
Heathcote, J. Godfrey ;
Khosroshahi, Arezou ;
Ferry, Judith A. ;
Aalberse, Rob C. ;
Bloch, Donald B. ;
Brugge, William R. ;
Bateman, Adrian C. ;
Carruthers, Mollie N. ;
Chari, Suresh T. ;
Cheuk, Wah ;
Cornell, Lynn D. ;
Fernandez-Del Castillo, Carlos ;
Forcione, David G. ;
Hamilos, Daniel L. ;
Kamisawa, Terumi ;
Kasashima, Satomi ;
Kawa, Shigeyuki ;
Kawano, Mitsuhiro ;
Lauwers, Gregory Y. ;
Masaki, Yasufumi ;
Nakanuma, Yasuni ;
Notohara, Kenji ;
Okazaki, Kazuich ;
Ryu, Ji Kon ;
Saeki, Takako ;
Sahani, Dushyant V. ;
Smyrk, Thomas C. ;
Stone, James R. ;
Takahira, Masayuki ;
Webster, George J. ;
Yamamoto, Motohisa ;
Zamboni, Giuseppe ;
Umehara, Hisanori ;
Stone, John H. .
MODERN PATHOLOGY, 2012, 25 (09) :1181-1192
[4]   Usefulness of 2-[18F]-fluoro-2-deoxy-D-glucose-Positron Emission Tomography/Computed Tomography for Staging and Evaluation of Treatment Response in IgG4-Related Disease: A Retrospective Multicenter Study [J].
Ebbo, Mikael ;
Grados, Aurelie ;
Guedj, Eric ;
Gobert, Delphine ;
Colavolpe, Cecile ;
Zaidan, Mohamad ;
Masseau, Agathe ;
Bernard, Fanny ;
Berthelot, Jean-Marie ;
Morel, Nathalie ;
Lifermann, Francois ;
Palat, Sylvain ;
Haroche, Julien ;
Mariette, Xavier ;
Godeau, Bertrand ;
Bernit, Emmanuelle ;
Costedoat-Chalumeau, Nathalie ;
Papo, Thomas ;
Hamidou, Mohamed ;
Harle, Jean-Robert ;
Schleinitz, Nicolas .
ARTHRITIS CARE & RESEARCH, 2014, 66 (01) :86-96
[5]   Signaling domains of the interleukin 2 receptor [J].
Gaffen, SL .
CYTOKINE, 2001, 14 (02) :63-77
[6]   A novel concept of Mikulicz's disease as IgG4-related disease [J].
Himi, Tetsuo ;
Takano, Kenichi ;
Yamamoto, Motohisa ;
Naishiro, Yasuyoshi ;
Takahashi, Hiroki .
AURIS NASUS LARYNX, 2012, 39 (01) :9-17
[7]   STRUCTURE OF THE HUMAN INTERLEUKIN-2 RECEPTOR GENE [J].
LEONARD, WJ ;
DEPPER, JM ;
KANEHISA, M ;
KRONKE, M ;
PEFFER, NJ ;
SVETLIK, PB ;
SULLIVAN, M ;
GREENE, WC .
SCIENCE, 1985, 230 (4726) :633-639
[8]   Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy [J].
Liao, Wei ;
Lin, Jian-Xin ;
Leonard, Warren J. .
IMMUNITY, 2013, 38 (01) :13-25
[9]   IgG4-related Diseases Including Mikulicz's Disease and Sclerosing Pancreatitis: Diagnostic Insights [J].
Masaki, Yasufumi ;
Sugai, Susumu ;
Umehara, Hisanori .
JOURNAL OF RHEUMATOLOGY, 2010, 37 (07) :1380-1385
[10]   Soluble IL-2 Receptor, a New Marker for Autoimmune Pancreatitis [J].
Matsubayashi, Hiroyuki ;
Uesaka, Katsuhiko ;
Kanemoto, Hideyuki ;
Asakura, Koiku ;
Kakushima, Naomi ;
Tanaka, Masaki ;
Kimura, Hirokazu ;
Ono, Hiroyuki .
PANCREAS, 2012, 41 (03) :493-496