Transfer of celecoxib into human milk

被引:31
作者
Hale, TW [1 ]
McDonald, R [1 ]
Boger, J [1 ]
机构
[1] Texas Tech Univ, Sch Med, Dept Pediat, Amarillo, TX 79106 USA
关键词
breastfeeding; celecoxib; lactation; NSAID;
D O I
10.1177/0890334404269875
中图分类号
R47 [护理学];
学科分类号
1011 ;
摘要
The aim of this study was to investigate the transfer of celecoxib into human milk. In one group of 3 breastfeeding patients on celecoxib at steady state, milk levels were determined at set intervals over 24 hours. Plasma levels were determined in 2 of their infants, age 17 and 22 months. In a second group of 2 subjects, intravenous lines were placed and a single 200-mg dose of celecoxib was followed by multiple paired plasma and milk samples over 8 hours. The mean milk-to-plasma ratio for celecoxib was 0.23 (95% confidence interval [Cl]: 0.15-0.31). The average concentration of celecoxib in milk during the 8-hour dosing interval was 66 mug/L (95% CI: 41-89). The absolute infant dose averaged 9.8 mug/kg/d (95% CI: 6.2-13.4); the mean relative infant dose was 0.30%. Therefore, the average clinical dose transferred to the infant daily would be approximately 0.3% of the weight-adjusted maternal dose. The authors suggest that the use of celecoxib in breastfeeding mothers at these doses is very unlikely to cause untoward effects in breastfed infants.
引用
收藏
页码:397 / 403
页数:7
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