Diabetes and increased lipid peroxidation are associated with systemic inflammation even in well-controlled patients

被引:61
作者
Bastos, Alliny de Souza [1 ]
Graves, Dana T. [2 ]
de Melo Loureiro, Ana Paula [3 ]
Rossa Junior, Carlos [1 ]
Tfaile Corbi, Samia Cruz [4 ]
Frizzera, Fausto [5 ]
Scarel-Caminaga, Raquel Mantuaneli [4 ]
Camara, Niels Olsen [6 ]
Andriankaja, Oelisoa M. [7 ]
Hiyane, Meire I. [6 ]
Perez Orrico, Silvana Regina [1 ]
机构
[1] UNESP Univ Estadual Paulista, Araraquara Sch Dent, Dept Diag & Surg, Rua Humaita 1680,2 Andar, BR-14801903 Sao Paulo, Brazil
[2] Univ Penn, Sch Dent Med, Dept Periodont, Philadelphia, PA 19104 USA
[3] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo, Brazil
[4] UNESP Univ Estadual Paulista, Sch Dent Araraquara, Dept Morphol, Araraquara, SP, Brazil
[5] Dent Sch, Fac Integradas Espirito Santenses FAESA, Vitoria, ES, Spain
[6] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Sao Paulo, Brazil
[7] Univ Puerto Rico, Sch Dent Med, Ctr Clin Res & Hlth Promot, San Juan, PR USA
基金
巴西圣保罗研究基金会;
关键词
Lipid peroxidation; Diabetes mellitus type 2; Cytokines; Dyslipidemia; Inflammation; NECROSIS-FACTOR-ALPHA; GLYCATION END-PRODUCTS; C-REACTIVE PROTEIN; OXIDATIVE STRESS; PLASMA INTERLEUKIN-6; INSULIN-RESISTANCE; CYTOKINES; LDL; ATHEROSCLEROSIS; HYPERGLYCEMIA;
D O I
10.1016/j.jdiacomp.2016.07.011
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: The effect of the interaction between type 2 diabetes and dyslipidemia on inflammation and lipid peroxidation (LPO) has not been assessed. Aim: To investigate whether diabetes coupled with dyslipidemia alters oxidative metabolism leading to increased LPO products and inflammatory status. Methods: 100 patients were divided into four groups based upon diabetic and dyslipidemic status: poorly controlled diabetes with dyslipidemia (DM-PC/D), well-controlled diabetes with dyslipidemia (DM-WC/D), normoglycemic individuals with dyslipidemia (NG/D), and normoglycemic individuals without dyslipidemia (NG/ND). Plasma was evaluated for an LPO product (MDA), antioxidant levels and inflammatory cytokines. Results: Diabetics presented significantly higher levels of LPO (p < 0.05) and the DM-PC/D had higher levels of proinflammatory cytokines and MDA in the plasma in comparison with normoglycemics (p < 0.05). Interestingly IL1-beta, IL-6, and TNF-alpha in DM-WC/D were not statistically different from those in DM-PC/D. Normoglycemic individuals with dyslipidemia presented significantly increased levels of IL-6 and TNF-alpha. when compared to normoglycemic without dyslipidemia (p < 0.05). MDA levels were also positively correlated with the presence of DM complications (r = 0.42, p < 0.01). Conclusions: These findings show that dyslipidemia is associated with an increased inflammatory status, even in well-controlled diabetics and in normoglycemics. Our results suggest that lipid metabolism and peroxidation are important for the development of inflammation, which is elevated in several complications associated with diabetes. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码:1593 / 1599
页数:7
相关论文
共 53 条
  • [1] Advanced glycation endproducts - role in pathology of diabetic complications
    Ahmed, N
    [J]. DIABETES RESEARCH AND CLINICAL PRACTICE, 2005, 67 (01) : 3 - 21
  • [2] American Diabetes Association, 2015, Clin Diabetes, V33, P97, DOI 10.2337/diaclin.33.2.97
  • [3] Enhanced acute-phase response and oxidative stress in older adults with type II diabetes
    Arnalich, F
    Hernanz, A
    López-Maderuelo, D
    Peña, JM
    Camacho, J
    Madero, R
    Vázquez, JJ
    Montiel, C
    [J]. HORMONE AND METABOLIC RESEARCH, 2000, 32 (10) : 407 - 412
  • [4] Protein oxidation parameters in type 2 diabetic patients with good and poor glycaemic control
    Çakatay, U
    [J]. DIABETES & METABOLISM, 2005, 31 (06) : 551 - 557
  • [5] Interleukin-6 and tumor necrosis factor-α are not increased in patients with Type 2 diabetes:: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness
    Carey, AL
    Bruce, CR
    Sacchetti, M
    Anderson, MJ
    Olsen, DB
    Saltin, B
    Hawley, JA
    Febbraio, MA
    [J]. DIABETOLOGIA, 2004, 47 (06) : 1029 - 1037
  • [6] The role of reactive oxygen and antioxidant species in periodontal tissue destruction
    Chapple, Iain L. C.
    Matthews, John B.
    [J]. PERIODONTOLOGY 2000, 2007, 43 : 160 - 232
  • [7] Advanced glycation end products in diabetic patients with optimized glycaemic control and their effects on endothelial reactivity: possible implications in venous graft failure
    Chello, Massimo
    Spadaccio, Cristiano
    Lusini, Mario
    Covino, Elvio
    Blarzino, Carla
    De Marco, Federico
    Di Domenico, Fabio
    Coccia, Raffaella
    [J]. DIABETES-METABOLISM RESEARCH AND REVIEWS, 2009, 25 (05) : 420 - 426
  • [8] LIPOPROTEIN OXIDATION AND LIPOPROTEIN-INDUCED CELL INJURY IN DIABETES
    CHISOLM, GM
    IRWIN, KC
    PENN, MS
    [J]. DIABETES, 1992, 41 : 61 - 66
  • [9] Increased Lipid Peroxidation in LDL from Type-2 Diabetic Patients
    Colas, Romain
    Pruneta-Deloche, Valerie
    Guichardant, Michel
    Luquain-Costaz, Celine
    Cugnet-Anceau, Christine
    Moret, Myriam
    Vidal, Hubert
    Moulin, Philippe
    Lagarde, Michel
    Calzada, Catherine
    [J]. LIPIDS, 2010, 45 (08) : 723 - 731
  • [10] Enhanced lipid peroxidation and platelet activation in the early phase of type 1 diabetes mellitus -: Role of interleukin-6 and disease duration
    Davì, G
    Chiarelli, F
    Santilli, F
    Pomilio, M
    Vigneri, S
    Falco, A
    Basili, S
    Ciabattoni, G
    Patrono, C
    [J]. CIRCULATION, 2003, 107 (25) : 3199 - 3203