Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): An Interplay among Drugs, Viruses, and Immune System

被引：181

作者：

Cho, Yung-Tsu

Yang, Che-Wen

Chu, Chia-Yu ^{[1
]}

机构：

[1] Natl Taiwan Univ Hosp, Dept Dermatol, Taipei 10002, Taiwan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 06期

关键词：

drug reaction with eosinophilia and systemic symptoms; drug-induced hypersensitivity syndrome; histopathology; pathogenesis; human herpesviruses-6; treatment; prognosis; INDUCED HYPERSENSITIVITY SYNDROME; HUMAN-HERPESVIRUS; 6; CUTANEOUS ADVERSE-REACTIONS; TOXIC EPIDERMAL NECROLYSIS; REGULATED CHEMOKINE TARC/CCL17; STEVENS-JOHNSON-SYNDROME; LONG-TERM SEQUELAE; T-CELLS; HUMAN-HERPESVIRUS-6; REACTIVATION; HLA-B-ASTERISK-5801; ALLELE;

D O I：

10.3390/ijms18061243

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe multiorgan hypersensitivity reaction mostly caused by a limited number of eliciting drugs in patients with a genetic predisposition. Patients with DRESS syndrome present with characteristic but variable clinical and pathological features. Reactivation of human herpesviruses (HHV), especially HHV-6, is the hallmark of the disease. Anti-viral immune responses intertwined with drug hypersensitivity make the disease more complicated and protracted. In recent years, emerging studies have outlined the disease more clearly, though several important questions remain unresolved. In this review, we provide an overview of DRESS syndrome, including clinical presentations, histopathological features, pathomechanisms, and treatments.

引用

页数：21

共 127 条

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