6-Substituted-5H-pyrrolo[2,3-b]pyrazines via palladium-catalyzed heteroannulation from N-(3-chloropyrazin-2-yl)methanesulfonamide and alkynes

被引：25

作者：

Hopkins, CR ^{[1
]}

Collar, N ^{[1
]}

机构：

[1] Aventis Pharmaceut, Drug Innovat & Approval, Dept Med Chem, Bridgewater, NJ 08807 USA

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 43期

关键词：

6-substituted-5H-pyrrolo[2,3-b]pyrazine; heteroannulation; palladium; cyclization;

D O I：

10.1016/j.tetlet.2004.08.155

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We herein report the efficient and convenient synthesis of 6-substituted-5H-pyrrolo[2,3-b]pyrazines. The reaction is a palladium-catalyzed heteroannulation process followed by deprotection to yield the desired pyrrolo[2,3-b]pyrazine substrates. The reaction starts with readily accessible N-(3-chloropyrazin-2-yl)-methanesulfonamide and commercially available terminal alkynes and works with aryl- and alkylalkynes. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：8087 / 8090

页数：4

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