Downregulation of Hepatic Stem Cell Factor By Vivo-Morpholino Treatment Inhibits Mast Cell Migration and Decreases Biliary Damage and Liver Fibrosis in Mdr2-/-mice

被引:0
|
作者
Hargrove, Laura [1 ]
Demieville, Jennifer [2 ]
Kennedy, Lindsey [1 ]
Meadows, Vik [2 ]
Smith, Steven [3 ]
Francis, Heather L. [4 ]
机构
[1] Texas A&M COM HSC, Med Physiol, Bryan, TX USA
[2] Cent Texas Vet Hlth Care Syst, Temple, TX USA
[3] Baylor Scott & White Hlth, Dallas, TX USA
[4] Texas A&M Hlth Sci Ctr, Med Physiol, Bryan, TX USA
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
1448
引用
收藏
页码:829A / 829A
页数:1
相关论文
共 37 条
  • [21] Activation of the HDC/histamine axis by reintroduction of mast cells or histamine treatment induces hepatobiliary damage, liver inflammation and fibrosis in Mdr2-/-/HDC-/- double knockout mice
    Hargrove, Laura
    Demieville, Jennifer
    Kennedy, Lindsey
    Thomson, Joanne
    Stephenson, Kristen
    Francis, Heather L.
    HEPATOLOGY, 2017, 66 : 101A - 102A
  • [22] Human and rat hepatic stellate cells produce stem cell factor:: a possible mechanism for mast cell recruitment in liver fibrosis
    Gaça, MDA
    Pickering, JA
    Arthur, MJP
    Benyon, RC
    JOURNAL OF HEPATOLOGY, 1999, 30 (05) : 850 - 858
  • [23] The reintroduction of mast cells into mast cell-deficient KitW-sh mice increases inflammation and enhances biliary damage and hepatic fibrosis
    Hargrove, Laura
    Demieville, Jennifer
    Kennedy, Lindsey
    Jones, Hannah
    Bernuzzi, Francesca
    Invernizzi, Pietro
    Alpini, Gianfranco
    Francis, Heather L.
    HEPATOLOGY, 2016, 64 : 175A - 175A
  • [24] miR-125b targets l-histidine decarboxylase (HDC) and inhibition of HDC decreases biliary proliferation, VEGF signaling and hepatic fibrosis in Mdr2-/- mice
    Demieville, Jennifer
    Hargrove, Laura
    Kennedy, Lindsey
    Jones, Hannah
    Smith, Steven
    Stephenson, Kristen
    Meng, Fanyin
    Francis, Heather L.
    HEPATOLOGY, 2017, 66 : 212A - 212A
  • [25] Reintroduction of mast cells induces biliary damage/senescence, steatosis, inflammation and hepatic fibrosis in mast cell deficient mice fed high fat diet
    Kennedy, Lindsey
    Demieville, Jennifer
    Hargrove, Laura
    Bailey, Jennifer M.
    Dar, Wasim A.
    Thomson, Joanne
    Meng, Fanyin
    Polireddy, Kishore
    Jones, Hannah
    Francis, Heather L.
    HEPATOLOGY, 2017, 66 : 1078A - 1078A
  • [26] Inhibition of Mast Cell-Derived TGF-β1 Decreases Biliary Damage and Hepatic Fibrosis in a Murine Model of Primary Sclerosing Cholangitis
    Kennedy, Lindsey
    Hargrove, Laura
    Demieville, Jennifer
    Meadows, Vik
    Smith, Steven
    Francis, Heather L.
    HEPATOLOGY, 2018, 68 : 181A - 182A
  • [27] HIGH FAT DIET-INDUCED BILIARY DAMAGE, STEATOSIS, INFLAMMATION AND HEPATIC FIBROSIS ARE DECREASED IN MAST CELL-DEFICIENT MICE
    Kennedy, Lindsey
    Demieville, Jennifer
    Hargrove, Laura
    Francis, Heather L.
    GASTROENTEROLOGY, 2017, 152 (05) : S1067 - S1067
  • [28] Reintroduction of Mast Cells Induces Biliary Damage/Senescence, Steatosis, Inflammation, and Hepatic Fibrosis in Mast Cell Deficient Mice Fed High-Fat Diet
    Kennedy, L.
    Demieville, J.
    Hargrove, L.
    Bailey, J.
    Dar, W.
    Thomson, J.
    Meng, F.
    Polireddy, K.
    Jones, H.
    Alpini, G.
    Francis, H.
    AMERICAN JOURNAL OF PATHOLOGY, 2017, 187 (10): : 2364 - 2365
  • [29] Selective inhibition of hepatic stellate cell and fibroblast-derived LOXL1 attenuates BDL- and Mdr2-/--induced cholestatic liver fibrosis
    Yan, Xuzhen
    Zhang, Ning
    Wei, Luyang
    Zhang, Wen
    Huang, Tao
    Li, Weiyu
    Chen, Wei
    Yang, Aiting
    You, Hong
    AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2023, 325 (06): : G608 - G621
  • [30] Mast Cells Contribute to Hepatic Neurokinin1 Receptor Signaling, Subsequent Biliary Damage and Peribiliary Fibrosis Via TGF-β1 Signaling in MDR2-/- Mouse Model of Primary Scelrosing Cholangitis
    Kundu, Debjyoti
    Zhou, Tianhao
    Meadows, Vik
    Kennedy, Lindsey
    Ceci, Ludovica
    Kyritsi, Konstantina
    Glaser, Shannon
    Alpini, Gianfranco
    Francis, Heather
    FASEB JOURNAL, 2022, 36