Paeonol promoted 2-aminofluorene and p-aminobenzoic acid acetylations by mononuclear leucocytes from Sprague-Dawley rats

被引：0
作者：
Chang, HL
Hung, CF
Yeh, CC
Chang, WC
Chung, JG
机构：
[1] China Med Coll, Dept Microbiol, Taichung 400, Taiwan
[2] China Med Coll, Dept Pharmacol, Taichung 400, Taiwan
[3] China Med Coll, Dept Physiol, Taichung 400, Taiwan
[4] Jen Ai Hosp, Dept Surg, Taichung 400, Taiwan
[5] China Med Coll Hosp, Dept Urol, Taichung 400, Taiwan
来源：
CYTOBIOS | 2000年 / 103卷 / 404期
关键词：
ellagic acid; N-acetyltransferase; 2-aminofluorene; p-aminobenzoic acid;
D O I：
暂无
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Following exposure of rats to the arylamine carcinogen 2-aminofluorene, DNA-carcinogen adducts were found in the target tissues of the liver and bladder, and also in circulating leucocytes. This work investigated how paeonol affects arylamine (2-aminofluorene and p-aminobenzoic acid) acetylations in rat leucocytes. Evidence is presented showing that rat mononuclear leucocytes are capable of acetylating 2-aminofluorene and p-aminobenzoic acid. Paeonol promoted 2-aminofluorene and p-aminobenzoic acid acetylation. Cultured lymphocytes produced about twice as much N-acetyl-P-aminofluorene from 2-aminofluorene and 2.2-fold as much N-acetyl-p-aminobenzoic acid from p-aminobenzoic acid as monocytes. After cotreatment with paeonol, the lymphocyte and monocyte cultures indicated that paeonol did increase 2-aminofluorene and p-aminobenzoic acid acetylations.
引用
收藏
页码：149 / 158
页数：10
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