Bioenergetic dysfunction and inflammation in Alzheimer's disease: a possible connection

被引：42

作者：

Wilkins, Heather M. ^{[1
,2
]}

Carl, Steven M. ^{[2
]}

Greenlief, Alison C. S. ^{[2
]}

Festoff, Barry W. ^{[1
,3
,4
,5
]}

Swerdlow, Russell H. ^{[1
,2
,4
,6
]}

机构：

[1] Univ Kansas, Med Ctr, Dept Neurol, Kansas City, KS 66160 USA

[2] Univ Kansas, Med Ctr, Alzheimers Dis Ctr, Kansas City, KS 66160 USA

[3] Univ Kansas, Med Ctr, Dept Pharmacol, Kansas City, KS 66160 USA

[4] Univ Kansas, Med Ctr, Dept Mol & Integrat Physiol, Kansas City, KS 66160 USA

[5] PHLOGISTIX Neurodiagnost, Lenexa, KS USA

[6] Univ Kansas, Med Ctr, Dept Biochem & Mol Biol, Kansas City, KS 66160 USA

来源：

FRONTIERS IN AGING NEUROSCIENCE | 2014年 / 6卷

关键词：

inflammation; bioenergetics; DAMP; mitochondria; Alzheimer's disease; TUMOR-NECROSIS-FACTOR; MITOCHONDRIAL TRANSCRIPTION FACTOR; POSITRON EMISSION TOMOGRAPHY; CEREBROSPINAL-FLUID LEVELS; MICROGLIAL NADPH OXIDASE; GENOME-WIDE ASSOCIATION; MATERNAL FAMILY-HISTORY; CENTRAL-NERVOUS-SYSTEM; CYTOCHROME-C-OXIDASE; FACTOR-ALPHA RELEASE;

D O I：

10.3389/fnagi.2014.00311

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Inflammation is observed in Alzheimers disease (AD) subject brains. Inflammation-relevant genes are increasingly implicated in AD genetic studies, and inflammatory cytokines to some extent even function as peripheral biomarkers. What underlies AD inflammation is unclear, but no foreign agent has been implicated. This suggests that internally produced damage-associated molecular pattern (DAMPs) molecules may drive inflammation in AD. A more complete characterization and understanding of AD-relevant DAMPs could advance our understanding of AD and suggest novel therapeutic strategies. In this review, we consider the possibility that mitochondria, intracellular organelles that resemble bacteria in many ways, trigger and maintain chronic inflammation in AD subjects. Data supporting the possible nexus between AD-associated bioenergetic dysfunction are discussed.

引用

页数：13

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