Anti-oxidative, anti-secretory and anti-inflammatory activities of the extract from the root bark of Lycium chinense (Cortex Lycii) against gastric ulcer in mice

被引：34

作者：

Chen, Hongxia ^{[1
,2
,3
]}

Olatunji, Opeyemi J. ^{[3
]}

Zhou, Yifeng ^{[1
,2
,4
]}

机构：

[1] Inst Bot, 1 Qianhuhoucun,POB 1435, Nanjing 210014, Jiangsu, Peoples R China

[2] Chinese Acad Sci, Nanjing Bot Garden Mem Sun Yat Sen, 1 Qianhuhoucun,POB 1435, Nanjing 210014, Jiangsu, Peoples R China

[3] Jiangsu Univ, Sch Pharm, Zhenjiang 212013, Peoples R China

[4] Chinese Acad Sci, Nanjing Branch, Dongtai Inst Tidal Flat, Dongtai 224200, Peoples R China

来源：

JOURNAL OF NATURAL MEDICINES | 2016年 / 70卷 / 03期

关键词：

Lycium chinense; Cortex Lycii; Antioxidant; Ethanol; Anti-inflammatory; OXIDATIVE STRESS; ANTIULCEROGENIC ACTIVITY; MUCOSAL INJURY; ESSENTIAL OIL; RATS; CONSTITUENTS; INVOLVEMENT; OFFICINALIS; FLAVONOIDS; FRACTIONS;

D O I：

10.1007/s11418-016-0984-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The evaluation of the antioxidant, anti-secretory and anti-inflammatory potentials of the ethyl acetate fraction (ELC) from the root bark of Lycium chinense against ethanol-induced gastric ulcer in mice and the possible mechanisms underlying this action was performed. The results indicated that oral administration of ELC (50, 100, 200 and 400 mg/kg) before ethanol-induced ulcer increased the gastric mucus content, restored the superoxide dismutase and glutathione levels, reduced malondialdehyde levels and inhibited the activity of myeloperoxidase. Furthermore, ELC displayed its anti-secretory activity by decreasing the gastric juice and increased the gastric pH and reduced pro-inflammatory markers and caspase-3 tissue levels. These results suggest that L. chinense displays gastroprotective properties as a result of its antioxidant, anti-inflammatory, anti-secretory and anti-apoptotic effects.

引用

页码：610 / 619

页数：10

共 47 条

[1] Protective role of ellagitannins from Eucalyptus citriodora against ethanol-induced gastric ulcer in rats: Impact on oxidative stress, inflammation and calcitonin-gene related peptide [J].