Enhancement of antitumor immunity by CTLA-4 blockade

被引：2947

作者：

Leach, DR

Krummel, MF

Allison, JP

机构：

[1] UNIV CALIF BERKELEY,CANC RES LAB,BERKELEY,CA 94720

[2] UNIV CALIF BERKELEY,DEPT MOLEC & CELL BIOL,BERKELEY,CA 94720

来源：

SCIENCE | 1996年 / 271卷 / 5256期

关键词：

D O I：

10.1126/science.271.5256.1734

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

One reason for the poor immunogenicity of many tumors may be that they cannot provide signals for CD28-mediated costimulation necessary to fully activate T cells. It has recently become apparent that CTLA-4, a second counterreceptor for the B7 family of costimulatory molecules, is a negative regulator of T cell activation. Here, in vivo administration of antibodies to CTLA-4 resulted in the rejection of tumors, including preestablished tumors. Furthermore, this rejection resulted in immunity to a secondary exposure to tumor cells. These results suggest that blockade of the inhibitory effects of CTLA-4 can allow for, and potentiate, effective immune responses against tumor cells.

引用

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页码：1734 / 1736

页数：3

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