Silver-Catalyzed C-H Trifluoromethylation of Arenes Using Trifluoroacetic Acid as the Trifluoromethylating Reagent

被引：111

作者：

Shi, Guangfa

Shao, Changdong

Pan, Shulei

Yu, Jingxun

Zhang, Yanghui ^{[1
]}

机构：

[1] Tongji Univ, Dept Chem, Shanghai 200092, Peoples R China

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 01期

基金：

中国国家自然科学基金;

关键词：

PD(II)-CATALYZED ORTHO-TRIFLUOROMETHYLATION; OXIDATIVE TRIFLUOROMETHYLATION; PERFLUOROALKANESULFONYL CHLORIDES; DIRECT PERFLUOROALKYLATION; HETEROAROMATIC-COMPOUNDS; AROMATIC-COMPOUNDS; FLUORINE; HETEROARENES; COPPER; HALIDES;

D O I：

10.1021/ol503189j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Direct trifluoromethylation of arenes using TFA as the trifluoromethylating reagent was achieved with Ag as the catalyst. This reaction not only provides a new protocol for aryl CH trifluoromethylation, but the generation of CF3 from TFA may prove useful in other contexts and could potentially be extended to other trifluoromethylation reactions.

引用

页码：38 / 41

页数：4

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