Identification of Chemo and Radio-Resistant Sub-Population of Stem Cells in Human Cervical Cancer HeLa Cells

被引：16

作者：

Abdel-Hamid, Nabil Mohie ^{[1
]}

Fathy, Moustafa ^{[2
,3
]}

Koike, Chika ^{[3
]}

Yoshida, Toshiko ^{[3
]}

Okabe, Motonori ^{[3
]}

Zho, Kaixuan ^{[3
]}

Abouzied, Mekky ^{[3
]}

Nikaido, Toshio ^{[3
]}

机构：

[1] Kafrelsheikh Univ, Dept Biochem, Fac Pharm, Kafr Al Sheikh, Egypt

[2] Minia Univ, Dept Biochem, Fac Pharm, Kafr Al Sheikh, Egypt

[3] Univ Toyama, Grad Sch Med & Pharmaceut Sci, Dept Regenerat Med, Toyama, Japan

来源：

CANCER INVESTIGATION | 2021年 / 39卷 / 08期

关键词：

Cancer stem cells; HeLa cells; CD44; CD24; stemness markers; tumorigenicity; chemoresistance; radio-resistance; INITIATING CELLS; MARKERS; TUMORS; CARCINOMA; RECURRENT;

D O I：

10.1080/07357907.2021.1931875

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background Cervical cancer ranks the second female malignancy after breast cancer. Cancer stem cells (CSCs) are hard to be eradicated, so can recur. We aim to isolate and characterize CSCs from HeLa cells. Methods These cells express clusters of differentiation (CDs), 44 and 24, to be sorted by fluorescence-activated cell sorting (FACS). Results CD44(+)CD24(+) cells showed potential to form spheres, tumorigenicity, stemness genes and higher resistance to cisplatin, X-ray. Conclusion CD44(+)CD24(+) HeLa cells hold characteristics of CSCs, in vitro, in vivo studies, suggesting that targeting may lead to screening of new anti-cancer therapies.

引用

页码：661 / 674

页数：14

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