Risk Factors of Recurrence in Patients With Clinical Stage IA Adenocarcinoma Presented as Ground-Glass Nodule

被引:27
作者
Su, Hang [1 ]
Dai, Chenyang [1 ]
Xie, Huikang [2 ]
Ren, Yijiu [1 ]
She, Yunlang [1 ]
Kadeer, Xiermaimaiti [1 ]
Xie, Dong [1 ]
Zheng, Hui [1 ]
Jiang, Gening [1 ]
Chen, Chang [1 ]
机构
[1] Tongji Univ, Sch Med, Shanghai Pulm Hosp, Dept Thorac Surg, Shanghai 200433, Peoples R China
[2] Tongji Univ, Sch Med, Shanghai Pulm Hosp, Dept Pathol, Shanghai, Peoples R China
关键词
Consolidation diameter to tumor diameter ratio; Limited resection; Lung adenocarcinoma; Risk factor; Surgical procedure; CELL LUNG-CANCER; RESOLUTION COMPUTED-TOMOGRAPHY; LIMITED-RESECTION TRIAL; SUBLOBAR RESECTION; WEDGE RESECTION; PROGNOSTIC-SIGNIFICANCE; SOLID TUMORS; OPACITY; LOBECTOMY; SURVIVAL;
D O I
10.1016/j.cllc.2018.04.020
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Patients in the ground-glass opacity (GGO)-dominant subgroup had a better prognosis than those in solid-dominant subgroup. Multivariate analysis confirmed that consolidation diameter to tumor diameter ratio was an independent risk factor of recurrence. In the analysis of solid-dominant subgroups, limited resection was an independent risk factor of recurrence. As to the GGO-dominant subgroup, surgical type was not a risk factor of recurrence in these patients. Background: In this study we aimed to identify the risk factors of recurrence in patients with clinical stage IA adenocarcinoma presented as ground glass nodule (GGN) on computed tomography scans. Patients and Methods: The study included 245 patients with clinical stage IA adenocarcinoma presented as GGN who underwent surgery during 2010 to 2013. All patients were divided into 2 subgroups on the basis of consolidation diameter to tumor diameter (C/T) ratio on lung window: (1) ground-glass opacity (GGO)-dominant subgroup (C/T < 0.5; n = 179); (2) solid-dominant subgroup (C/T > 0.5; n = 66). Recurrence-free survival (RFS) was analyzed to identify independent risk factors of recurrence using the Kaplan-Meier approach and multivariable Cox models. Results: Patients in the GGO-dominant subgroup had a better prognosis than those in the solid-dominant subgroup (5-year RFS: 98% vs. 87%; P < .001). Multivariate analysis confirmed that C/T ratio was an independent risk factor for RFS in patients with clinical stage IA adenocarcinoma presented as GGN (hazard ratio [HR], 9.47; 95% confidence interval [CI], 1.75-51.1; P = .009). In the analysis of the solid-dominant group, multivariate analysis showed that limited resection was an independent risk factor of recurrence in this subgroup (HR, 6.86; 95% CI, 1.50-31.42; P = .013). Regarding the GGO-dominant subgroup, surgical type was not a risk factor of recurrence. Conclusion: Patients with clinical stage IA solid-dominant adenocarcinoma (C/T ratio > 0.5) had a higher rate of recurrence after limited resection than lobectomy. Thus, limited resection should be performed cautiously in these patients (C/T ratio > 0.5). (C) 2018 Elsevier Inc. All rights reserved.
引用
收藏
页码:E609 / E617
页数:9
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