Clinical activity of sequential flavopiridol, cytosine arabinoside, and mitoxantrone for adults with newly diagnosed, poor-risk acute myelogenous leukemia

被引：58

作者：

Karp, Judith E. ^{[1
]}

Blackford, Amanda ^{[1
]}

Smith, B. Douglas ^{[1
]}

Alino, Katrina ^{[1
]}

Seung, Amy Hatfield ^{[1
]}

Bolanos-Meade, Javier ^{[1
]}

Greer, Jacqueline M. ^{[1
]}

Carraway, Hetty E. ^{[1
]}

Gore, Steven D. ^{[1
]}

Jones, Richard J. ^{[1
]}

Levis, Mark J. ^{[1
]}

McDevitt, Michael A. ^{[1
]}

Doyle, L. Austin ^{[2
]}

Wright, John J. ^{[2
]}

机构：

[1] Sidney Kimmel Comprehens Canc Ctr Johns Hopkins, Baltimore, MD 21231 USA

[2] NCI, Invest Drug Branch, Canc Therapy Evaluat Program, Div Canc Treatment & Diag, Bethesda, MD 20892 USA

来源：

LEUKEMIA RESEARCH | 2010年 / 34卷 / 07期

关键词：

Flavopiridol; AML; Poor risk; Timed sequential therapy; ACUTE MYELOID-LEUKEMIA; PHASE-II; KINASE; CELLS; INHIBITORS; TRANSCRIPTION; RESISTANCE; INDUCTION; APOPTOSIS; L86-8275;

D O I：

10.1016/j.leukres.2009.11.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Flavopiridol, a cyclin-dependent kinase inhibitor, is cytotoxic to leukemic blasts. In a Phase II study, flavopiridol 50mg/m(2) was given by 1-h infusion daily x 3 beginning day 1 followed by 2 g/m(2)/72 h ara-C beginning day 6 and 40mg/m(2) mitoxantrone on day 9 (FLAM) to 45 adults with newly diagnosed acute myelogenous leukemia (AML) with multiple poor-risk features. Thirty patients (67%) achieved complete remission (CR) and 4 (9%) died. Twelve (40%) received myeloablative allogeneic bone marrow transplant (BMT) in first CR. Median OS and DFS are not reached (67% alive 12.5-31 months, 58% in CR 11.4-30 months), with median follow-up 22 months. Sixteen received FLAM in CR, with median OS and DFS 9 and 13.1 months, and 36% alive at 21-31 months. Short OS and DFS correlated with adverse cytogenetics, regardless of age or treatment in CR. The addition of allogeneic BMT in CR translates into long OS and DFS in the majority of eligible patients. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：877 / 882

页数：6

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