Pregnane X receptor and natural products: beyond drug-drug interactions

被引：67
作者：
Staudinger, Jeff L.
Ding, Xunshan
Lichti, Kristin
机构：
[1] Univ Kansas, Dept Pharmacol & Toxicol, Lawrence, KS 66045 USA
[2] Univ Texas, SW Med Ctr, Dallas, TX 77390 USA
来源：
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY | 2006年 / 2卷 / 06期
关键词：
drug interaction; herb; nuclear receptor; pregnane X receptor; xenobiotic response;
D O I：
10.1517/17425255.2.6.847
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The pregnane X receptor (PXR, NR112) is a member of the nuclear receptor superfamily that is activated by a myriad of compounds and natural products in clinical use. Activation of PXR represents the basis for several clinically important drug-drug interactions. Although PXR activation has undesirable effects in patients on combination therapy, it also mediates the hepato-protective effects exhibited by some herbal remedies. This review focuses on PXR activation by natural products and the potential therapeutic opportunities presented. In particular, the biological effects of St. John's Wort, gugulipid, kava kava, Coleus forskolii, Hypoxis, Sutherlandia, cling hao, wu wei zi, gan cao and other natural products are discussed. The impact of these natural products on drug metabolism and hepatoprotection is highlighted in the context of activation and antagonism of PXR.
引用
收藏
页码：847 / 857
页数：11
相关论文
共 69 条
[1]   FORSKOLIN - FROM AN AYURVEDIC REMEDY TO A MODERN AGENT [J].
AMMON, HPT ;
MULLER, AB .
PLANTA MEDICA, 1985, 51 (06) :473-477
[2]  
Ashton M, 1998, DRUG METAB DISPOS, V26, P25
[3]  
BACHS L, 1989, LANCET, V1, P574
[4]  
Beg M., 1996, Indian Journal of Physiology and Pharmacology, V40, P237
[5]   Kava-kava and anxiety: Growing knowledge about the efficacy and safety [J].
Bilia, AR ;
Gallon, S ;
Vincieri, FF .
LIFE SCIENCES, 2002, 70 (22) :2581-2597
[6]   SXR, a novel steroid and xenobiotic-sensing nuclear receptor [J].
Blumberg, B ;
Sabbagh, W ;
Juguilon, H ;
Bolado, J ;
van Meter, CM ;
Ono, ES ;
Evans, RM .
GENES & DEVELOPMENT, 1998, 12 (20) :3195-3205
[7]   Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane X receptor [J].
Brobst, DE ;
Ding, XS ;
Creech, KL ;
Goodwin, B ;
Kelley, B ;
Staudinger, JL .
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2004, 310 (02) :528-535
[8]   Antimalarial artemisinin drugs induce cytochrome p450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor [J].
Burk, O ;
Arnold, KA ;
Nussler, AK ;
Schaeffeler, E ;
Efimova, E ;
Avery, BA ;
Avery, MA ;
Fromm, MF ;
Eichelbaum, M .
MOLECULAR PHARMACOLOGY, 2005, 67 (06) :1954-1965
[9]   The hypolipidemic natural product guggulsterone is a promiscuous steroid receptor ligand [J].
Burris, TP ;
Montrose, C ;
Houck, KA ;
Osborne, HE ;
Bocchinfuso, WP ;
Yaden, BC ;
Cheng, CC ;
Zink, RW ;
Barr, RJ ;
Hepler, CD ;
Krishnan, V ;
Bullock, HA ;
Burris, LL ;
Galvin, RJ ;
Bramlett, K ;
Stayrook, KR .
MOLECULAR PHARMACOLOGY, 2005, 67 (03) :948-954
[10]   Unexpected clinical remission of cholestasis after rifampicin therapy in patients with normal or slightly increased levels of γ-glutamyl transpeptidase [J].
Cançado, ELR ;
Leitao, RMC ;
Carrilho, FJ ;
Laudanna, AA .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 1998, 93 (09) :1510-1517
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