Inhibition of leukotriene biosynthesis by stilbenoids from Stemona species

被引：47

作者：

Adams, M

Pacher, T

Greger, H

Bauer, R ^{[1
]}

机构：

[1] Graz Univ, Dept Pharmacognosy, Inst Pharmaceut Sci, A-8010 Graz, Austria

[2] Univ Vienna, Inst Bot, Comparat & Ecol Phytochem Dept, A-1030 Vienna, Austria

来源：

JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 01期

关键词：

D O I：

10.1021/np0497043

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Fifteen stilbenoids and two alkaloids from Stemona collinsae, S. tuberosa, and S. peirrei were tested alongside the commercially available stilbenoids resveratrol and pinosylvin for inhibition of leukotriene formation in an ex vivo test system based on activated human neutrophilic granulocytes. The stilbenoids resveratrol (1), pinosylvin (2), dihydropinosylvin (3), stilbostemin A (4), stilbostemin B (5), stilbostemin D (6), stilbostemin F (7), stilbostemin G (8), stemofuran B (9), stemofuran C (10), stemofuran D (11), stemofuran G (12), stemofuran J (13), stemanthrene A (14), stemanthrene B (15), stemanthrene C (16), and stemanthrene D (17) showed structure-dependent activities with IC(50) values ranging from 3.7 to > 50 muM. The alkaloids tuberostemonine (18) and neotuberostemonine (19) were inactive at a concentration of 50 muM.

引用

页码：83 / 85

页数：3

共 14 条

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