Hepatosplenic T-cell lymphoma in adolescents and young adults with Crohn's disease: A cautionary tale?

被引：178

作者：

Rosh, Joel R. ^{[1
]}

Gross, Thomas

Mamulo, Petar

Griffiths, Anne

Hyams, Jeffrey

机构：

[1] Goryeb Childrens Hosp Atlantic Hlth, Morristown, NJ 07962 USA

[2] Columbus Childrens Hosp, Columbus, OH USA

[3] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA

[4] Toronto Sick Childrens Hosp, Toronto, ON, Canada

[5] Connecticut Childrens Med Ctr, Hartford, CT USA

来源：

INFLAMMATORY BOWEL DISEASES | 2007年 / 13卷 / 08期

关键词：

infliximab; lymphoma; thiopurines; Crohn's disease; pediatrics;

D O I：

10.1002/ibd.20169

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Therapy for the inflammatory bowel diseases increasingly includes the use of immune-modifying and biologic therapies. Recently, in young patients with IBD, an association has been noted between the use of infliximab along with concomitant purine analogues and the development of hepatosplenic T-cell lymphoma (HSTCL)-a rare and all but incurable form of non-Hodgkin's lymphoma. This report briefly reviews the issue of lymphoma and IBD therapy. Additionally, a description of HSTCL and a summary of the known cases of this apparent therapeutic complication are presented. Clinical options in light of this new information are explored.

引用

页码：1024 / 1030

页数：7

共 53 条

[51] Hepatosplenic T-cell lymphoma in an adolescent patient after immunomodulator and biologic therapy for Crohn disease [J].

Thayu, M ;

Markowitz, JE ;

Mamula, P ;

Russo, TA ;

Muinos, WI ;

Baldassano, RN .

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2005, 40 (02) :220-222

[52]

van Assche GA, 2006, GASTROENTEROLOGY, V130, pA142

[53] Hepatosplenic T cell lymphoma. A review on 45 cases since the first report describing the disease as a distinct lymphoma entity in 1990 [J].

Weidmann, E .

LEUKEMIA, 2000, 14 (06) :991-997

← 1 2 3 4 5 6 →