Modeling withdrawal syndrome in zebrafish

被引：143

作者：

Cachat, Jonathan ^{[1
,2
]}

Canavello, Peter ^{[1
,2
]}

Elegante, Marco ^{[1
,2
]}

Bartels, Brett ^{[1
,2
]}

Hart, Peter ^{[1
,2
,3
]}

Bergner, Carisa ^{[3
]}

Egan, Rupert ^{[3
]}

Duncan, Ashley ^{[1
,2
]}

Tien, David ^{[1
,2
]}

Chung, Amanda ^{[1
,2
]}

Wong, Keith ^{[1
,2
]}

Goodspeed, Jason ^{[1
,2
]}

Tan, Julia ^{[1
,2
]}

Grimes, Chelsea ^{[1
,2
]}

Elkhayat, Salem ^{[1
,2
]}

Suciu, Christopher ^{[1
,2
]}

Rosenberg, Michael ^{[1
,2
]}

Chung, Kyung Min ^{[1
,2
]}

Kadri, Ferdous ^{[1
,2
]}

Roy, Sudipta ^{[1
,2
]}

Gaikwad, Siddharth ^{[1
,2
]}

Stewart, Adam ^{[1
,2
]}

Zapolsky, Ivan ^{[1
,2
]}

Gilder, Thomas ^{[1
,2
]}

Mohnot, Sopan ^{[1
,2
]}

Beeson, Esther ^{[1
,2
]}

Amri, Hakima ^{[3
]}

Zukowska, Zofia ^{[3
]}

Soignier, R. Denis ^{[4
]}

Kalueff, Allan V. ^{[1
,2
]}

机构：

[1] Tulane Univ, Sch Med, Dept Pharmacol, New Orleans, LA 70112 USA

[2] Tulane Univ, Sch Med, Neurosci Program, New Orleans, LA 70112 USA

[3] Georgetown Univ, Sch Med, Stress Physiol & Res Ctr SPaRC, Dept Physiol & Biophys, Washington, DC 20057 USA

[4] Univ New Orleans, Dept Psychol, New Orleans, LA 70148 USA

来源：

BEHAVIOURAL BRAIN RESEARCH | 2010年 / 208卷 / 02期

关键词：

Zebrafish; Stress; Anxiety; Withdrawal; Novel tank test; Cortisol; COCAINE-DEPENDENT INDIVIDUALS; CHRONIC ETHANOL EXPOSURE; NICOTINE WITHDRAWAL; SALIVARY CORTISOL; DRUG-WITHDRAWAL; SEX-DIFFERENCES; ANIMAL-MODELS; CAFFEINE WITHDRAWAL; ALCOHOL-WITHDRAWAL; LOCOMOTOR-ACTIVITY;

D O I：

10.1016/j.bbr.2009.12.004

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The zebrafish (Danio rerio) is rapidly becoming a popular model species in behavioral neuroscience research. Zebrafish behavior is robustly affected by environmental and pharmacological manipulations, and can be examined using exploration-based paradigms, paralleled by analysis of endocrine (cortisol) stress responses. Discontinuation of various psychotropic drugs evokes withdrawal in both humans and rodents, characterized by increased anxiety. Sensitivity of zebrafish to drugs of abuse has been recently reported in the literature. Here we examine the effects of ethanol, diazepam, morphine and caffeine withdrawal on zebrafish behavior. Overall, discontinuation of ethanol, diazepam and morphine produced anxiogenic-like behavioral or endocrine responses, demonstrating the utility of zebrafish in translational research of withdrawal syndrome. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：371 / 376

页数：6

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