Synthesis and Characterization of Gelatin-Based Crosslinkers for the Fabrication of Superabsorbent Hydrogels

被引：30

作者：

Amonpattaratkit, Penphitcha ^{[1
]}

Khunmanee, Sureerat ^{[1
]}

Kim, Dong Hyun ^{[2
]}

Park, Hansoo ^{[1
]}

机构：

[1] Chung Ang Univ, Dept Integrat Engn, Seoul 156756, South Korea

[2] Korea Inst Ind Technol, Gyeonggi 15588, South Korea

来源：

MATERIALS | 2017年 / 10卷 / 07期

基金：

新加坡国家研究基金会;

关键词：

gelatin; methacrylic anhydride; itaconic acid; swelling; biodegradation; superabsorbent hydrogels; METHACRYLATE HYDROGELS; SWELLING BEHAVIOR; HYALURONIC-ACID; DEGRADATION; RELEASE; LINKING;

D O I：

10.3390/ma10070826

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In this work, crosslinkers were prepared by conjugating high-and low-molecular-weight gelatin with different mole ratios of itaconic acid (IA) with double bonds. Then, the gelatin-itaconic acid (gelatin-IA) crosslinkers were compared with the gelatin-methacrylate (gelatin-MA) crosslinkers. The molecular weights and structures of gelatin-MA and gelatin-IA were confirmed using gel permeation chromatography (GPC) and nuclear magnetic resonance (NMR). Additionally, the swelling ratio and biodegradation properties of the hydrogels using IA as starting monomers and gelatin-IA and gelatin-MA as crosslinkers were investigated. Both hydrogels prepared with high and low molecular weights of gelatin-IA showed higher swelling ratios than those prepared with the gelatin-MA. The results also showed that absorbent hydrogels with different biodegradabilities and swelling ratios could be prepared by changing the ratio of the gelatin-based crosslinkers.

引用

页数：10

共 20 条

[1] 25th Anniversary Article: Rational Design and Applications of Hydrogels in Regenerative Medicine [J].