Novel formulation of glucocorticoid based on silver alginate microcapsules for intraarticular drug delivery

被引：4
作者：
Lengert, Ekaterina [1 ,2 ]
Saveleva, Mariia [1 ,2 ]
Verkhovskii, Roman [1 ]
Abramova, Anna [1 ]
Goryacheva, Irina [1 ]
机构：
[1] Saratov NG Chernyshevskii State Univ, 83 Astrakhanskaya, Saratov 410012, Russia
[2] Saratov State Med Univ, Bolshaya Kazachya 112, Saratov 410012, Russia
来源：
MATERIALS LETTERS | 2021年 / 288卷
关键词：
Silver alginate microcapsules; Intraarticular drug delivery; Betamethasone; Ultrasound-triggered release; Osteoarthritis therapy; CYTOTOXICITY; MICROSPHERES;
D O I：
10.1016/j.matlet.2021.129339
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
The development of drug delivery systems for glucocorticoid drugs is a new strategy for optimization of glucocorticoid therapy, allowing the reduction of systemic side effects and the prolongation of a therapeutic one. For intraarticular glucocorticoids injection, widely used for therapy of osteoarthritis, the prolongation of drug release might also reduce the needle injection damage of a joint, due to reducing the number of injections operations. The current study introduces the novel system for water-insoluble glucocorticoid betamethasone delivery, based on silver alginate microcapsules, providing improved bioavailability, enhanced loading efficiency, and sustained release. The proposed system opens up the prospects for osteoarthritis therapy, enabling to overcome limitations of the intraarticular delivery of glucocorticoids. (C) 2021 Elsevier B.V. All rights reserved.
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页数：4
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