Correlation of long interspersed element-1 open reading frame 1 and c-Met proto-oncogene protein expression in ovarian cancer

被引：6

作者：

Ko, Eun-Ji ^{[1
,2
,3
]}

Oh, Young Lim ^{[4
,5
]}

Kim, Heung Yeol ^{[4
,5
]}

Eo, Wan Kyu ^{[6
]}

Kim, Hongbae ^{[7
]}

Ock, Mee Sun ^{[1
,2
]}

Kim, Heui-Soo ^{[3
]}

Kim, Ki Hyung ^{[8
,9
,10
]}

Cha, Hee-Jae ^{[1
,2
]}

机构：

[1] Kosin Univ, Coll Med, Dept Parasitol, Busan, South Korea

[2] Kosin Univ, Coll Med, Dept Genet, Busan, South Korea

[3] Pusan Natl Univ, Dept Biol Sci, Coll Nat Sci, Busan, South Korea

[4] Kosin Univ, Coll Med, Dept Obstet, Busan, South Korea

[5] Kosin Univ, Coll Med, Dept Gynecol, Busan, South Korea

[6] Kyung Hee Univ, Dept Internal Med, Seoul, South Korea

[7] Hallym Univ, Dept Obstet & Gynecol, Coll Med, Chunchon, South Korea

[8] Pusan Natl Univ, Dept Obstet & Gynecol, Sch Med, Busan, South Korea

[9] Pusan Natl Univ Hosp, Biomed Res Inst, Busan, South Korea

[10] Pusan Natl Univ Hosp, Pusan Canc Ctr, Busan, South Korea

来源：

GENES & GENOMICS | 2019年 / 41卷 / 11期

关键词：

LINE-1; ORF1; c-Met; Methylation; Expression; Ovarian cancer; SMALL-MOLECULE INHIBITOR; LINE-1; HYPOMETHYLATION; HELICOBACTER-PYLORI; PROGNOSTIC-FACTOR; PATHWAY; OVEREXPRESSION; PROGRESSION; METASTASIS; TARGET; ALU;

D O I：

10.1007/s13258-019-00858-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background Hypomethylation of long interspersed nuclear element-1 (LINE-1) is closely related to certain cancers and concerns with aggressive tumor behavior. Previously, we reported LINE-1 open reading frame-1 (ORF1) protein level was significantly up-regulated in ovarian cancers compared with normal ovary. Hypomethylation of local LINE-1 sequence has been reported to reactivate MET proto-oncogene in colon cancers and hepatocellular carcinoma. However, the relationship between LINE-1 and c-MET expressions in ovarian cancer is not yet studied. Method Here, we analyzed the expression patterns of LINE-1 ORF1 and c-Met protein in ovarian cancer tissue microarrays containing 208 surgical specimens including normal ovary and malignant ovarian cancers. Results The expressions of both LINE-1 ORF1 and c-Met protein were significantly increased in ovarian cancers and peaked in early stage of tumor. Other clinical data including age and tumor types were not significantly related with both proteins. Co-relationship between LINE-1 ORF1 and c-Met protein was significant (p = 0.03) but several patients show different expression patterns. Conclusions These results propose that LINE-1 ORF1 significantly activates c-Met but not in all cases, suggesting other factors may be involved simultaneously.

引用

页码：1293 / 1299

页数：7

共 28 条

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