Coordinating cell cycle-regulated histone gene expression through assembly and function of the Histone Locus Body

被引：100
作者：
Duronio, Robert J. [1 ,2 ,3 ,4 ]
Marzluff, William F. [1 ,3 ,4 ,5 ]
机构：
[1] Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA
[3] Univ N Carolina, Integrat Program Biol & Genome Sci, CB 7100, Chapel Hill, NC 27599 USA
[4] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
[5] Univ N Carolina, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA
来源：
RNA BIOLOGY | 2017年 / 14卷 / 06期
关键词：
Cell cycle; Drosophila; histone genes; mRNA processing; nuclear body; PRE-MESSENGER-RNA; SMALL NUCLEAR-RNA; XENOPUS GERMINAL VESICLE; DROSOPHILA U7 SNRNP; PROCESSING IN-VIVO; S-PHASE ENTRY; CAJAL BODY; POLYADENYLATION FACTORS; E/CDK2; SUBSTRATE; POLYMERASE-II;
D O I：
10.1080/15476286.2016.1265198
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Metazoan replication-dependent (RD) histone genes encode the only known cellular mRNAs that are not polyadenylated. These mRNAs end instead in a conserved stem-loop, which is formed by an endonucleolytic cleavage of the pre-mRNA. The genes for all 5 histone proteins are clustered in all metazoans and coordinately regulated with high levels of expression during S phase. Production of histone mRNAs occurs in a nuclear body called the Histone Locus Body (HLB), a subdomain of the nucleus defined by a concentration of factors necessary for histone gene transcription and pre-mRNA processing. These factors include the scaffolding protein NPAT, essential for histone gene transcription, and FLASH and U7 snRNP, both essential for histone pre-mRNA processing. Histone gene expression is activated by Cyclin E/Cdk2-mediated phosphorylation of NPAT at the G1-S transition. The concentration of factors within the HLB couples transcription with pre-mRNA processing, enhancing the efficiency of histone mRNA biosynthesis.
引用
收藏
页码：726 / 738
页数：13
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