Thermal characterization of the solid state and raw material fluconazole by thermal analysis and pyrolysis coupled to GC/MS

被引：34

作者：

Moura, Elisana Afonso ^{[1
]}

Correia, Lidiane Pinto ^{[1
]}

Pinto, Marcia Ferraz ^{[1
]}

Virgulino Procopio, Jose Valdilanio ^{[1
]}

de Souza, Fabio Santos ^{[2
]}

Macedo, Rui Oliveira ^{[1
,2
]}

机构：

[1] Univ Fed Pernambuco, Dept Pharmaceut Sci, BR-740521 Recife, PE, Brazil

[2] Fed Univ Parahyba, Unified Labs Med Dev & Assay, BR-58059900 Joao Pessoa, Paraiba, Brazil

来源：

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY | 2010年 / 100卷 / 01期

关键词：

Thermal analysis; Pyrolysis; Fluconazole; QUALITY-CONTROL; DECOMPOSITION; BEHAVIOR; TG; MEBENDAZOLE; DSC;

D O I：

10.1007/s10973-009-0473-x

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

This article had studied the thermal characterization of the raw material and different fluconazole crystals, obtained through recrystallization with different solvents using thermoanalytical techniques (TG, DTA, DSC-50, DSC Photovisual, DSC-60) and Pyr-GC/MS. The results confirmed that the fluconazole volatilizes without decomposition until 250 A degrees C. Pyr-GC/MS showed hexachlorobenzene like impurities in fluconazole raw material.

引用

页码：289 / 293

页数：5

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