Coinfection of SCID-hu Thy/Liv mice with human herpesvirus 6 and human immunodeficiency virus type 1

被引：15

作者：

Gobbi, A

Stoddart, CA

Locatelli, G

Santoro, F

Bare, C

Linquist-Stepps, V

Moreno, ME

Abbey, NW

Herndier, BG

Malnati, MS

McCune, JM

Lusso, P

机构：

[1] San Raffaele Sci Inst, Unit Human Virol, DIBIT, Dept Biol & Technol Res, I-20132 Milan, Italy

[2] Univ Calif San Francisco, Dept Med, San Francisco, CA 94110 USA

[3] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94110 USA

[4] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94110 USA

[5] Univ Calif San Francisco, Gladstone Inst Virol & Immunol, San Francisco, CA 94110 USA

[6] Univ Bologna, Div Infect Dis, I-40138 Bologna, Italy

来源：

JOURNAL OF VIROLOGY | 2000年 / 74卷 / 18期

关键词：

D O I：

10.1128/JVI.74.18.8726-8731.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human herpesvirus 6 (HHV-6) has been proposed as a potential cofactor in the progression of human immunodeficiency virus type 1 (HIV-1) disease. me used the SCID-hu Thy/Liv mouse model to evaluate the in vivo interactions between HHV-6 and HIV-1. Our results demonstrate that HHV-6 and HIV-1 can simultaneously replicate in the human thymus in vivo. In this model, however, the presence of one virus appears not to modify the replication or cytopathicity of the other.

引用

收藏

页码：8726 / 8731

页数：6

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