Transgenic analysis of thymocyte signal transduction

被引：45
作者：
Cantrell, DA [1 ]
机构：
[1] Imperial Canc Res Fund, Lymphocyte Activiat Lab, London WC2A 3PX, England
来源：
NATURE REVIEWS IMMUNOLOGY | 2002年 / 2卷 / 01期
关键词：
D O I：
10.1038/nri703
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This review examines the value of transgenic studies in mice for the genetic dissection of signal-transduction pathways relevant to thymus development. T-cell development in the thymus is controlled by an ordered sequence of differentiation and proliferation checkpoints that culminate in the production of correctly selected, non-autoreactive, peripheral T lymphocytes. Work in transgenic mice has been fundamental for the preparation of genetic maps of signal-transduction pathways that control T-cell development. This review discusses how tyrosine kinases, guanine-nucleotide- binding proteins and transcription factors converge to control T-cell differentiation and proliferation in the immune system.
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页码：20 / 27
页数：8
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