TISIDB: an integrated repository portal for tumor-immune system interactions

被引：1666

作者：

Ru, Beibei ^{[1
]}

Wong, Ching Ngar ^{[1
]}

Tong, Yin ^{[1
]}

Zhong, Jia Yi ^{[1
]}

Zhong, Sophia Shek Wa ^{[1
]}

Wu, Wai Chung ^{[1
]}

Chu, Ka Chi ^{[1
]}

Wong, Choi Yiu ^{[1
]}

Lau, Chit Ying ^{[1
]}

Chen, Ian ^{[1
]}

Chan, Nam Wai ^{[1
]}

Zhang, Jiangwen ^{[1
]}

机构：

[1] Univ Hong Kong, Sch Biol Sci, Hong Kong 999077, Peoples R China

来源：

BIOINFORMATICS | 2019年 / 35卷 / 20期

关键词：

D O I：

10.1093/bioinformatics/btz210

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The interaction between tumor and immune system plays a crucial role in both cancer development and treatment response. To facilitate comprehensive investigation of tumor-immune interactions, we have designed a user-friendly web portal TISIDB, which integrated multiple types of data resources in oncoimmunology. First, we manually curated 4176 records from 2530 publications, which reported 988 genes related to anti-tumor immunity. Second, genes associated with the resistance or sensitivity of tumor cells to T cell-mediated killing and immunotherapy were identified by analyzing high-throughput screening and genomic profiling data. Third, associations between any gene and immune features, such as lymphocytes, immunomodulators and chemokines, were pre-calculated for 30 TCGA cancer types. In TISIDB, biologists can cross-check a gene of interest about its role in tumor-immune interactions through literature mining and high-throughput data analysis, and generate testable hypotheses and high quality figures for publication.

引用

页码：4200 / 4202

页数：3

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