Epigenetic factors in aging and longevity

被引：96
作者：
Gravina, Silvia [1 ]
Vijg, Jan [1 ]
机构：
[1] Albert Einstein Coll Med, Dept Genet, Bronx, NY 10461 USA
来源：
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2010年 / 459卷 / 02期
关键词：
Aging; Epigenetics; DNA methylation; Lifespan; GILFORD-PROGERIA-SYNDROME; DNA METHYLATION; CELLULAR SENESCENCE; GENE-EXPRESSION; HUMAN FIBROBLASTS; DYSDIFFERENTIATIVE NATURE; MUTATION ACCUMULATION; CYTOSINE METHYLATION; CALORIE RESTRICTION; IN-VIVO;
D O I：
10.1007/s00424-009-0730-7
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Epigenetics refers to phenotypic changes caused by mechanisms that are unrelated to changes in the underlying DNA sequence, most notably chromatin remodeling driven by histone modifications, and DNA methylation. Such variation is transmitted by cell division, but generally not passed on through the germ line. An increasing body of evidence supports a role for epigenetic changes in the etiology of aging and its associated disease sequelae. Here, we review the role of epigenetics in aging and longevity with a focus on DNA methylation. Increased understanding of those aging-related processes that are driven by epigenetic mechanisms will allow for the development of novel epigenetic-based diagnostic, preventive, and therapeutic strategies for age-related diseases.
引用
收藏
页码：247 / 258
页数：12
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