Multiple Synchronous Sporadic Gastrointestinal Stromal Tumors in the Stomach and Jejunum

被引：3

作者：

Tokunaga, Mami ^{[1
]}

Nanjo, Sohachi ^{[1
]}

Yoshita, Hiroki ^{[1
]}

Fujinami, Haruka ^{[1
]}

Watanabe, Tohru ^{[2
]}

Ishii, Yoko ^{[3
]}

Kobayashi, Saito ^{[1
]}

Akashi, Momoko ^{[1
]}

Takagi, Hiroaki ^{[1
]}

Mihara, Hiroshi ^{[1
]}

Kajiura, Shinya ^{[1
]}

Ando, Takayuki ^{[1
]}

Hashimoto, Isaya ^{[2
]}

Hojo, Shozo ^{[2
]}

Okumura, Tomoyuki ^{[2
]}

Sugiyama, Toshiro ^{[1
]}

机构：

[1] Univ Toyama, Grad Sch Med & Pharmaceut Sci, Dept Gastroenterol & Hematol, Toyama, Japan

[2] Univ Toyama, Grad Sch Med & Pharmaceut Sci, Dept Surg & Sci, Toyama, Japan

[3] Univ Toyama, Grad Sch Med & Pharmaceut Sci, Dept Pathol, Toyama, Japan

来源：

INTERNAL MEDICINE | 2018年 / 57卷 / 12期

关键词：

multiple GISTs; c-kit mutation; C-KIT; NEUROFIBROMATOSIS; MUTATIONS; GIST;

D O I：

10.2169/internalmedicine.0229-17

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 77-year-old patient was admitted to our hospital for the further examination of melena. A computed tomography scan detected two submucosal tumors (SMTs) in the stomach and jejunum. Double-balloon endoscopy revealed the presence of a delle on the jejunal SMT, suggesting that the SMT was the origin of the gastrointestinal bleeding. Both tumors were surgically resected and subsequently diagnosed via histology as gastrointestinal stromal tumors (GISTs). Furthermore, the two GISTs had different mutations in the c-kit gene, suggesting that they were derived from different clonal origins. This report depicts an extremely rare case of multiple synchronous sporadic GISTs in the stomach and jejunum.

引用

页码：1719 / 1723

页数：5

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