Elucidating TOR signaling and rapamycin action:: lessons from Saccharomyces cerevisiae

被引：291
|
作者：
Crespo, JL [1 ]
Hall, MN [1 ]
机构：
[1] Univ Basel, Biozentrum, Div Biochem, CH-4056 Basel, Switzerland
来源：
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS | 2002年 / 66卷 / 04期
关键词：
D O I：
10.1128/MMBR.66.4.579-591.2002
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. Rapamycin is an immunosuppressive and anticancer drug that acts by inhibiting TOR. The modes of action of TOR and rapamycin are remarkably conserved from S. cerevisiae to humans. The current understanding of TOR and rapamycin is derived largely from studies with S. cerevisiae. In this review, we discuss the contributions made by S. cerevisiae to understanding rapamycin action and TOR function.
引用
收藏
页码：579 / +
页数：14
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