Urinary cystatin C as a biomarker of early renal dysfunction in type 2 diabetic patients

被引:11
作者
Hassan, Mohamed [1 ]
Hatata, Elsayed Z. [2 ]
Al-Arman, Mohamed [3 ]
Aboelnaga, Mohamed M. [2 ]
机构
[1] Mansoura Univ, Specialized Med Hosp, Internal Med, Mansoura, Egypt
[2] Mansoura Univ, Fac Med, Endocrinol & Diabet Unit, Mansoura, Egypt
[3] Mansoura Univ, Fac Med, Clin Pathol Dept, Mansoura, Egypt
关键词
Albuminuria; GFR; Urinary cystatin C; Diabetes mellitus; Diabetic nephropathy; Tubular damage; GELATINASE-ASSOCIATED LIPOCALIN; NEPHROPATHY; ALBUMINURIA; CREATININE; DIAGNOSIS; EQUATION; ADULTS;
D O I
10.1016/j.dsx.2021.05.025
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aims: We aimed to evaluate urinary CysC (cystanin c) as an early marker of diabetic nephropathy in patients with type 2 diabetes and investigate the correlation of urinary CysC with albuminuria and GFR. Methodology: This case-controlled study was conducted on 66 type 2 diabetic patients who were clas-sified according to albuminuria into 3 groups and consisting of 20 healthy subjects as the control group. We assessed urinary CysC, urinary albumin excretion rate (UACR). Results: Urinary CysC levels were significantly higher in normoalbuminuric diabetic compared with healthy control and there was a progressive linear increase in urinary CysC levels with increasing albuminuria in the diabetic patients. Despite insignificant deference in creatinine between participants groups, we observed significant differences between these groups as regard eGFR, urinary CysC, and UACR. Urinary CysC did not have significant correlations with any clinical or biochemical parameters. Moreover, urinary CysC had a statistically significant association with albuminuria and eGFR. Conclusion: Urinary CysC levels correlated with UACR and GFR. It is linked to subclinical tubular injury and can be an earlier marker of kidney involvement, even before albuminuria and it is less influenced by non-renal factors. Therefore, Urinary CysC is useful biomarker for early diagnosis of diabetic nephropathy. (C) 2021 Diabetes India. Published by Elsevier Ltd. All rights reserved.
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页数:6
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