Tau plasma levels in subjective cognitive decline: Results from the DELCODE study

被引：30

作者：

Mueller, Stephan ^{[1
,2
]}

Preische, Oliver ^{[1
,2
,3
]}

Goepfert, Jens C. ^{[4
]}

Yanez, Viviana A. Carcamo ^{[4
]}

Joos, Thomas O. ^{[4
]}

Boecker, Henning ^{[5
]}

Duezel, Emrah ^{[6
]}

Falkai, Peter ^{[7
]}

Priller, Josef ^{[8
,9
,10
]}

Buerger, Katharina ^{[7
,11
]}

Catak, Cihan ^{[11
]}

Janowitz, Daniel ^{[11
]}

Heneka, Michael T. ^{[5
,12
]}

Brosseron, Frederic ^{[5
,12
]}

Nestor, Peter ^{[6
]}

Peters, Oliver ^{[8
,18
]}

Menne, Felix ^{[8
,18
]}

Schipke, Carola G. ^{[8
,19
]}

Schneider, Anja ^{[5
,13
]}

Spottke, Annika ^{[5
]}

Fliessbach, Klaus ^{[5
]}

Kilimann, Ingo ^{[14
]}

Teipel, Stefan ^{[14
]}

Wagner, Michael ^{[5
,15
]}

Wiltfang, Jens ^{[16
,20
]}

Jessen, Frank ^{[5
,17
]}

Laske, Christoph ^{[1
,2
,3
]}

机构：

[1] Univ Tubingen, Hertie Inst Clin Brain Res, Sect Dementia Res, Tubingen, Germany

[2] Univ Tubingen, Dept Psychiat & Psychotherapy, Tubingen, Germany

[3] German Ctr Neurodegenerat Dis DZNE, Tubingen, Germany

[4] Univ Tubingen, Nat & Med Sci Inst, Reutlingen, Germany

[5] German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

[6] German Ctr Neurodegenerat Dis DZNE, Magdeburg, Germany

[7] German Ctr Neurodegenerat Dis DZNE, Munich, Germany

[8] German Ctr Neurodegenerat Dis DZNE, Berlin, Germany

[9] Charite, Dept Neuropsychiat, Berlin, Germany

[10] Berlin Inst Hlth, Berlin, Germany

[11] Klinikum Univ Munchen, Inst Stroke & Dementia Res ISD, Munich, Germany

[12] Univ Hosp Bonn, Dept Neurol, Bonn, Germany

[13] Univ Hosp Bonn, Dept Neurodegenerat Dis & Gerontopsychiat, Bonn, Germany

[14] German Ctr Neurodegenerat Dis DZNE, Rostock, Germany

[15] Univ Hosp Bonn, Dept Psychiat, Bonn, Germany

[16] German Ctr Neurodegenerat Dis DZNE, Gottingen, Germany

[17] Univ Cologne, Med Fac, Dept Psychiat, Cologne, Germany

[18] Charite, Inst Psychiat & Psychotherapy, CBF, Berlin, Germany

[19] Charite, Inst Neuropathol, Berlin, Germany

[20] Univ Med Ctr Goettingen UMG, Dept Psychiat & Psychotherapy, Gottingen, Germany

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

关键词：

CEREBROSPINAL-FLUID; DEMENTIA; IMPAIRMENT; PROTEINS; RISK; MCI;

D O I：

10.1038/s41598-017-08779-0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Previous studies have demonstrated increased tau plasma levels in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) due to AD. Much less is known whether increased tau plasma levels can already be detected in the pre-MCI stage of subjective cognitive decline (SCD). In the present study we measured tau plasma levels in 111 SCD patients and 134 age- and gender-matched cognitively healthy controls participating in the DZNE (German Center for Neurodegenerative Diseases) longitudinal study on cognition and dementia (DELCODE). Tau plasma levels were measured using ultra-sensitive, single-molecule array (Simoa) technology. We found no significant different tau plasma levels in SCD (3.4 pg/ml) compared with healthy controls (3.6 pg/ml) after controlling for age, gender, and education (p = 0.137). In addition, tau plasma levels did not correlate with A beta 42 (r = 0.073; p = 0.634), tau (r = -0.179; p = 0.240), and p-tau181 (r = -0.208; p = 0.171) cerebrospinal fluid (CSF) levels in a subgroup of 45 SCD patients with available CSF. In conclusion, plasma tau is not increased in SCD patients. In addition, the lack of correlation between tau in plasma and CSF in the examined cohort suggests that tau levels are affected by different factors in both biofluids.

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