Structured Cognitive-Motor Dual Task Training Compared to Single Mobility Training in Persons with Multiple Sclerosis, a Multicenter RCT

被引:43
作者
Veldkamp, Renee [1 ]
Baert, Ilse [1 ]
Kalron, Alon [2 ]
Tacchino, Andrea [3 ]
D'hooge, Mieke [1 ,4 ]
Vanzeir, Ellen [5 ]
Van Geel, Fanny [1 ]
Raats, Joke [1 ,6 ]
Goetschalckx, Mieke [1 ]
Brichetto, Giampaolo [3 ,7 ]
Shalmoni, Nov [8 ]
Hellinckx, Peter [4 ]
De Weerdt, Natasja [5 ]
De Wilde, Dorien [6 ]
Feys, Peter [1 ]
机构
[1] Hasselt Univ, Fac Rehabil Sci, REVAL Rehabil Res Ctr, B-3500 Hasselt, Belgium
[2] Tel Aviv Univ, Sackler Fac Med, Sch Hlth Profess, Dept Phys Therapy, IL-6997801 Tel Aviv, Israel
[3] Italian MS Fdn FISM, Sci Res Area, I-16149 Genoa, Italy
[4] Natl MS Ctr Melsbroek, B-1820 Steenokkerzeel, Belgium
[5] Rehabil & MS Ctr Overpelt, B-3900 Pelt, Belgium
[6] De Mick AZ Klina, B-2930 Brasschaat, Belgium
[7] Italian Multiple Sclerosis Soc, AISM Rehabil Serv Genoa, I-16149 Genoa, Italy
[8] Sheba Med Ctr, Multiple Sclerosis Ctr, Derech Sheba 2, IL-5262100 Tel Hashomer, Israel
关键词
multiple sclerosis; cognitive motor interference; dual task; gait; balance; cognition; WALKING; INTERFERENCE; IMPAIRMENT; BALANCE; IMPACT; COST; PERFORMANCE; PATTERNS; DISEASE; MS;
D O I
10.3390/jcm8122177
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The aim was to compare the effectiveness of dual-task training (DTT) compared to single mobility training (SMT) on dual-task walking, mobility and cognition, in persons with Multiple Sclerosis (pwMS). Forty pwMS were randomly assigned to the DTT or SMT groups. The DTT-group performed dual-task exercises using an interactive tablet-based application, while the SMT-group received conventional walking and balance exercises. Both interventions were supervised and identical in weeks (8) and sessions (20). Nine cognitive-motor dual-task conditions were assessed at baseline, after intervention and at 4-weeks follow-up (FU). The dual-task cost (DTC), percentage change of dual-task performance compared to single-task performance, was the primary outcome. Mobility and cognition were secondarily assessed. Mixed model analyses were done with group, time and the interaction between group and time as fixed factors and participants as random factors. Significant time by group interactions were found for the digit-span walk and subtraction walk dual-task conditions, with a reduction in DTC (gait speed) for the DTT maintained at FU. Further, absolute dual-task gait speed during walking over obstacles only improved after the DTT. Significant improvements were found for both groups in various motor and cognitive measures. However, the DTT led to better dual-task walking compared to the SMT.
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页数:16
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