Cul-catalyzed Sonogashira reaction for the efficient synthesis of 1H-imidazo[2,1-a]isoquinoline derivatives

被引：26

作者：

Gang, Ma-Yong ^{[1
]}

Liu, Jian-Quan ^{[1
]}

Wang, Xiang-Shan ^{[1
]}

机构：

[1] Jiangsu Normal Univ, Sch Chem & Mat Sci, Jiangsu Key Lab Green Synth Funct Mat, Xuzhou 221116, Jiangsu, Peoples R China

来源：

TETRAHEDRON | 2017年 / 73卷 / 31期

关键词：

Sonogashira reaction; Hydroamination; Imidazoisoquinoline; CuI/o-phen; TERMINAL ALKYNES; ALKYNYLATION;

D O I：

10.1016/j.tet.2017.06.043

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Sonogashira reaction first, and then intra-molecular hydroamination of alkyne catalyzed by CuI/o-phen was proved to be an efficient method for the synthesis of imidazo[2,1-a]isoquinoline, phenanthro[9',10':4,5]imidazo[2,1-a]isoquinoline and acenaphtho[1',2':4,5]imidazo [2,1-a]isoquinoline derivatives in the presence of Cs2CO3. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：4698 / 4705

页数：8

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