Immunocontinuum: Perspectives in antimicrobial peptide mechanisms of action and resistance

被引：86
|
作者：
Yount, NY
Yeaman, MR
机构：
[1] Univ Calif Los Angeles, Div Infect Dis, St Johns Cardiovasc Res Ctr, Res & Los Angeles Biomed Res Ctr Harbor,Med Ctr, Torrance, CA 90502 USA
[2] Univ Calif Los Angeles, Ctr Med, Los Angeles Biomed Res Ctr Harbor, Los Angeles, CA 90059 USA
来源：
PROTEIN AND PEPTIDE LETTERS | 2005年 / 12卷 / 01期
关键词：
antimicrobial; peptide; resistance; mechanism;
D O I：
10.2174/0929866053405959
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Antimicrobial peptides are present in organisms spanning virtually every kingdom, and employ sophisticated mechanisms to exert rapid microbicidal action consistent with their key roles in host defense. Offsetting these mechanisms, some microbial pathogens have evolved complex countermeasures to neutralize exposure to and subvert mechanisms of antimicrobial peptides. The following discussion highlights recent advances that offer greater understanding of the mechanisms of action and resistance of antimicrobial peptides.
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页码：49 / 67
页数：19
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