Greening analytical chromatography

被引：292

作者：

Welch, Christopher J. ^{[1
]}

Wu, Naijun ^{[1
]}

Biba, Mirlinda ^{[1
]}

Hartman, Robert ^{[1
]}

Brkovic, Tanja ^{[1
]}

Gong, Xiaoyi ^{[1
]}

Helmy, Roy ^{[1
]}

Schafer, Wes ^{[1
]}

Cuff, James ^{[1
]}

Pirzada, Zainab ^{[1
]}

Zhou, Lili ^{[1
]}

机构：

[1] Merck & Co Inc, Separat & Purificat Ctr Excellence, Rahway, NJ 07065 USA

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2010年 / 29卷 / 07期

关键词：

Acetonitrile; Analytical separation; Ethanol; Fast chromatography; Green analytical chemistry; Microflow chromatography; Solvent saving; Supercritical-fluid chromatography; Superheated water chromatography; Waste; SUPERCRITICAL-FLUID CHROMATOGRAPHY; PERFORMANCE LIQUID-CHROMATOGRAPHY; SUPERHEATED DEUTERIUM-OXIDE; SPECTROSCOPIC ANALYSIS UV; RAPID METHOD DEVELOPMENT; MOBILE-PHASE; DRUG DISCOVERY; MONOLITHIC COLUMNS; STATIONARY PHASES; CHIRAL SEPARATION;

D O I：

10.1016/j.trac.2010.03.008

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We review recent approaches for greening analytical separation technologies. Whereas conventional analytical separation technologies produce as much as 50 mL of waste per analysis, greener options considerably reduce the amount of waste generated per analysis, ranging from simply adoptable small-particle stationary-phase technologies and reduced column diameters to more specialized technologies [e.g., ultra-high-pressure liquid chromatography (UHPLC), supercritical-fluid chromatography (SFC) and microscale or nanoscale HPLC]. In addition, greener eluents and chromatography conditions can also be used, including substitution of ethanol for acetonitrile in reversed-phase HPLC and the use of water alone as an eluent at elevated temperatures. We describe the merits of these emerging technologies, and discuss the factors influencing the decision to move from conventional analytical separation methodologies to greener alternatives. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：667 / 680

页数：14

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