Inhibitors of Galectins and Implications for Structure-Based Design of Galectin-Specific Therapeutics

被引:22
|
作者
Blanchard, Helen [1 ]
Bum-Erdene, Khuchtumur [1 ]
Hugo, Matthew W. [1 ]
机构
[1] Griffith Univ, Inst Glyc, Gold Coast Campus, Qld 4222, Australia
关键词
MODIFIED CITRUS PECTIN; CYCLODEXTRIN-BASED GLYCOCLUSTERS; ARGININE-ARENE INTERACTIONS; PROSTATE-CANCER; MAMMALIAN GALECTINS; TETRAVALENT GLYCOCLUSTERS; INDUCED APOPTOSIS; CELL APOPTOSIS; MESSENGER-RNA; TUMOR-GROWTH;
D O I
10.1071/CH14362
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Galectins are a family of galactoside-specific lectins that are involved in a myriad of metabolic and disease processes. Due to roles in cancer and inflammatory and heart diseases, galectins are attractive targets for drug development. Over the last two decades, various strategies have been used to inhibit galectins, including polysaccharide-based therapeutics, multivalent display of saccharides, peptides, peptidomimetics, and saccharide-modifications. Primarily due to galectin carbohydrate binding sites having high sequence identities, the design and development of selective inhibitors targeting particular galectins, thereby addressing specific disease states, is challenging. Furthermore, the use of different inhibition assays by research groups has hindered systematic assessment of the relative selectivity and affinity of inhibitors. This review summarises the status of current inhibitors, strategies, and novel scaffolds that exploit subtle differences in galectin structures that, in conjunction with increasing available data on multiple galectins, is enabling the feasible design of effective and specific inhibitors of galectins.
引用
收藏
页码:1763 / 1779
页数:17
相关论文
共 50 条
  • [41] Structure-Based Design of Macrocyclic Coagulation Factor Vila Inhibitors
    Priestley, E. Scott
    Cheney, Daniel L.
    DeLucca, Indawati
    Wei, Anzhi
    Luettgen, Joseph M.
    Rendina, Alan R.
    Wong, Pancras C.
    Wexler, Ruth R.
    JOURNAL OF MEDICINAL CHEMISTRY, 2015, 58 (15) : 6225 - 6236
  • [42] Structure-based design, synthesis and biological evaluation of β-glucuronidase inhibitors
    Khalid M. Khan
    Nida Ambreen
    Muhammad Taha
    Sobia A. Halim
    Shagufta Zaheer-ul-Haq
    Saima Naureen
    Shahnaz Rasheed
    Sajjad Perveen
    Mohammad Iqbal Ali
    Journal of Computer-Aided Molecular Design, 2014, 28 : 577 - 585
  • [43] Structure-Based Drug Design Studies on a Series of Aldolase Inhibitors
    Ferreira, Leonardo G.
    dos Santos, Ricardo N.
    Andricopulo, Adriano D.
    JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2013, 24 (02) : 201 - 211
  • [44] Structure-based design of a novel class of herbicidal HPPD inhibitors
    Viner, Russell
    Bhonoah, Yunas
    Langford, Mike
    Kloer, Daniel
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 252
  • [45] Structure-based design of selective calpain-2 inhibitors
    Luo, Yun
    Chatterjee, Payal
    Alsamarah, Abdelaziz
    Kent, David
    Baudry, Michel
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251
  • [46] Structure-based drug design of macrocyclic factor XIa inhibitors
    Corte, James
    Fang, Tianan
    Osuna, Honey
    Pinto, Donald
    Rossi, Karen
    Rendina, Alan
    Bozarth, Jeffrey
    Sheriff, Steven
    Myers, Joseph
    Harper, Timothy
    Lou, Zhen
    Zheng, Joanna
    Luettgen, Joseph
    Seiffert, Dietmar
    Lam, Patrick
    Wexler, Ruth
    Quan, Mimi
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 252
  • [47] STRUCTURE-BASED DESIGN OF NOVEL NONPEPTIDIC HIV PROTEASE INHIBITORS
    LOVASZ, KD
    MORRIS, JK
    TOMICH, PK
    WATENPAUGH, KD
    HOWE, WJ
    DOLAK, LA
    ROMINES, KR
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1995, 210 : 25 - MEDI
  • [48] Structure-based drug design of HIV protease inhibitors.
    Navia, MA
    Tung, RD
    Chaturvedi, PR
    Rao, BG
    Partaledis, JA
    Kim, EE
    FASEB JOURNAL, 1996, 10 (06): : 2436 - 2436
  • [49] Structure-based design of human carbonic anhydrase XII inhibitors
    Kugler, M.
    Brynda, J.
    Rezacova, P.
    Fabry, M.
    Kral, V.
    Pospisilova, K.
    Holub, J.
    Sicha, S.
    Nekvinda, J.
    Gruner, B.
    FEBS OPEN BIO, 2018, 8 : 426 - 427
  • [50] Structure-based design of acylguanidine BACE1 inhibitors
    Manas, ES
    Chopra, R
    Cole, DC
    Stock, JR
    Jennings, LD
    Lovering, FE
    Condon, JS
    Zhou, P
    Solvibile, WR
    Aulabaugh, A
    Lo, MC
    Cowling, R
    Jin, G
    Turner, MJ
    Hu, Y
    Wagner, E
    Fan, KY
    Alvarez, JC
    Malamas, MS
    Bard, J
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 230 : U1293 - U1294