Microscopic Plasmodium falciparum Gametocytemia and Infectivity to Mosquitoes in Cambodia

被引：40

作者：

Lin, Jessica T. ^{[1
]}

Ubalee, Ratawan ^{[4
]}

Lon, Chanthap ^{[6
]}

Balasubramanian, Sujata ^{[1
]}

Kuntawunginn, Worachet ^{[5
]}

Rahman, Rifat ^{[1
]}

Saingam, Piyaporn ^{[5
]}

Thay Kheang Heng ^{[7
]}

Dav Vy ^{[8
]}

San, Savoeun ^{[9
]}

Nuom, Sarath ^{[6
]}

Burkly, Hana ^{[5
]}

Chanarat, Nitima ^{[5
]}

Ponsa, Chanudom ^{[4
]}

Levitz, Lauren ^{[2
]}

Parobek, Christian ^{[3
]}

Chuor, Char Meng ^{[7
]}

Somethy, Sok ^{[8
]}

Spring, Michele ^{[5
]}

Lanteri, Charlotte ^{[5
]}

Gosi, Panita ^{[5
]}

Meshnick, Steven R. ^{[2
]}

Saunders, David L. ^{[5
]}

机构：

[1] Univ N Carolina, Sch Med, Div Infect Dis, 130 Mason Farm Rd,Ste 2115,CB 7030, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, 130 Mason Farm Rd,Ste 2115,CB 7030, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Curriculum Genet & Mol Biol, 130 Mason Farm Rd,Ste 2115,CB 7030, Chapel Hill, NC 27599 USA

[4] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand

[5] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand

[6] Armed Forces Res Inst Med Sci, Phnom Penh, Cambodia

[7] Natl Malaria Ctr, Phnom Penh, Cambodia

[8] Royal Cambodian Armed Forces, Phnom Penh, Cambodia

[9] Battambang Referral Hosp, Battambang, Cambodia

来源：

JOURNAL OF INFECTIOUS DISEASES | 2016年 / 213卷 / 09期

关键词：

gametocyte; membrane feeding; infectious reservoir; malaria transmission; Plasmodium falciparum; submicroscopic; Anopheles dirus; MALARIA INFECTIONS; TRANSMISSION; RELEVANCE;

D O I：

10.1093/infdis/jiv599

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although gametocytes are essential for malaria transmission, in Africa many falciparum-infected persons without smear-detectable gametocytes still infect mosquitoes. To see whether the same is true in Southeast Asia, we determined the infectiousness of 119 falciparum-infected Cambodian adults to Anopheles dirus mosquitoes by membrane feeding. Just 5.9% of subjects infected mosquitoes. The 8.4% of patients with smear-detectable gametocytes were >20 times more likely to infect mosquitoes than those without and were the source of 96% of all mosquito infections. In low-transmission settings, targeting transmission-blocking interventions to those with microscopic gametocytemia may have an outsized effect on malaria control and elimination.

引用

页码：1491 / 1494

页数：4

共 15 条

[1] Asymptomatic malaria infections: detectability, transmissibility and public health relevance [J].

Bousema, Teun ;

Okell, Lucy ;

Felger, Ingrid ;

Drakeley, Chris .

NATURE REVIEWS MICROBIOLOGY, 2014, 12 (12) :833-840

[2] Mosquito Feeding Assays to Determine the Infectiousness of Naturally Infected Plasmodium falciparum Gametocyte Carriers [J].

Bousema, Teun ;

Dinglasan, Rhoel R. ;

Morlais, Isabelle ;

Gouagna, Louis C. ;

van Warmerdam, Travis ;

Awono-Ambene, Parfait H. ;

Bonnet, Sarah ;

Diallo, Mouctar ;

Coulibaly, Mamadou ;

Tchuinkam, Timoleon ;

Mulder, Bert ;

Targett, Geoff ;

Drakeley, Chris ;

Sutherland, Colin ;

Robert, Vincent ;

Doumbo, Ogobara ;

Toure, Yeya ;

Graves, Patricia M. ;

Roeffen, Will ;

Sauerwein, Robert ;

Birkett, Ashley ;

Locke, Emily ;

Morin, Merribeth ;

Wu, Yimin ;

Churcher, Thomas S. .

PLOS ONE, 2012, 7 (08)

[3] Epidemiology and Infectivity of Plasmodium falciparum and Plasmodium vivax Gametocytes in Relation to Malaria Control and Elimination [J].

Bousema, Teun ;

Drakeley, Chris .

CLINICAL MICROBIOLOGY REVIEWS, 2011, 24 (02) :377-+

[4]

Carter R., 1988, MALARIA PRINCIPLES P, P253

[5] Predicting mosquito infection from Plasmodium falciparum gametocyte density and estimating the reservoir of infection [J].

Churcher, Thomas S. ;

Bousema, Teun ;

Walker, Martin ;

Drakeley, Chris ;

Schneider, Petra ;

Ouedraogo, Andre Lin ;

Basanez, Maria-Gloria .

ELIFE, 2013, 2

[6] The role of submicroscopic parasitemia in malaria transmission: what is the evidence? [J].

Lin, Jessica T. ;

Saunders, David L. ;

Meshnick, Steven R. .

TRENDS IN PARASITOLOGY, 2014, 30 (04) :183-190

[7] Plasmodium falciparum Gametocyte Carriage Is Associated with Subsequent Plasmodium vivax Relapse after Treatment [J].

Lin, Jessica T. ;

Bethell, Delia ;

Tyner, Stuart D. ;

Lon, Chanthap ;

Shah, Naman K. ;

Saunders, David L. ;

Sriwichai, Sabaithip ;

Khemawoot, Phisit ;

Kuntawunggin, Worachet ;

Smith, Bryan L. ;

Noedl, Harald ;

Schaecher, Kurt ;

Socheat, Duong ;

Se, Youry ;

Meshnick, Steven R. ;

Fukuda, Mark M. .

PLOS ONE, 2011, 6 (04)

[8] The remarkable journey of adaptation of the Plasmodium falciparum malaria parasite to New World anopheline mosquitoes [J].

Molina-Cruz, Alvaro ;

Barillas-Mury, Carolina .

MEMORIAS DO INSTITUTO OSWALDO CRUZ, 2014, 109 (05) :662-667

[9]

Musapa M, 2013, JOVE-J VIS EXP, V9, P3281, DOI DOI 10.3791/3281

[10] Factors determining the occurrence of submicroscopic malaria infections and their relevance for control [J].

Okell, Lucy C. ;

Bousema, Teun ;

Griffin, Jamie T. ;

Ouedraogo, Andre Lin ;

Ghani, Azra C. ;

Drakeley, Chris J. .

NATURE COMMUNICATIONS, 2012, 3

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