Increased levels of homocysteine in patients with ulcerative colitis

被引:16
作者
Akbulut, Sabiye [2 ]
Altiparmak, Emin [3 ]
Topal, Firdevs [4 ]
Ozaslan, Ersan [3 ]
Kucukazman, Metin [5 ]
Yonem, Ozlem [1 ]
机构
[1] Cumhuriyet Univ, Cumhuriyet Univ Hastanesi, Dept Gastroenterol, TR-58140 Sivas, Turkey
[2] Kartal Kosuyolu High Specialty Educ & Res Hosp, Dept Gastroenterol, TR-34846 Istanbul, Turkey
[3] Ankara Numune Training & Educ Hosp, Dept Gastroenterol, TR-06443 Ankara, Turkey
[4] Cankiri State Hosp, Dept Gastroenterol, TR-18200 Cankiri, Turkey
[5] Kecioren Teaching & Res Hosp, Dept Gastroenterol, TR-06380 Ankara, Turkey
关键词
Ulcerative colitis; Homocysteine; Folate; Vitamin B12; INFLAMMATORY-BOWEL-DISEASE; SERUM TOTAL HOMOCYSTEINE; PROTEIN-S DEFICIENCY; VENOUS THROMBOSIS; CROHNS-DISEASE; RISK-FACTOR; CARDIOVASCULAR-DISEASE; PLASMA HOMOCYSTEINE; C RESISTANCE; HYPERHOMOCYSTEINEMIA;
D O I
10.3748/wjg.v16.i19.2411
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
AIM: To investigate serum levels of homocysteine (Hcys) and the risk that altered levels carry for thrombosis development in ulcerative colitis (UC) patients. METHODS: 55 UC patients and 45 healthy adults were included. Hcys, vitamin B12 and folic acid levels were measured in both groups. Clinical history and thromboembolic events were investigated. RESULTS: The average Hcys level in the UC patients was 13.3 +/- 1.93 mu mmol/L (range 4.60-87) and was higher than the average Hcys level of the control group which was 11.2 +/- 3.58 mu mmol/L (range 4.00-20.8) (P < 0.001). Vitamin B12 and folic acid average values were also lower in the UC group (P < 0.001). When multivariate regression analysis was performed, it was seen that folic acid deficiency was the only risk factor for hyperhomocysteinemia. Frequencies of thromboembolic complications were not statistically significantly different in UC and control groups. When those with and without a thrombosis history in the UC group were compared according to Hcys levels, it was seen that there were no statistically significant differences. A negative linear relationship was found between folic acid levels and Hcys. CONCLUSION: We could not find any correlations between Hcys levels and history of prior thromboembolic events. (C) 2010 Baishideng. All rights reserved.
引用
收藏
页码:2411 / 2416
页数:6
相关论文
共 55 条
[1]   FREE PROTEIN-S DEFICIENCY IN PATIENTS WITH CHRONIC INFLAMMATORY BOWEL-DISEASE [J].
AADLAND, E ;
ODEGAARD, OR ;
ROSETH, A ;
TRY, K .
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1992, 27 (11) :957-960
[2]   FREE PROTEIN-S DEFICIENCY IN PATIENTS WITH CROHNS-DISEASE [J].
AADLAND, E ;
ODEGAARD, OR ;
ROSETH, A ;
TRY, K .
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1994, 29 (04) :333-335
[3]   SERUM TOTAL HOMOCYSTEINE AND CORONARY HEART-DISEASE [J].
ARNESEN, E ;
REFSUM, H ;
BONAA, KH ;
UELAND, PM ;
FORDE, OH ;
NORDREHAUG, JE .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 1995, 24 (04) :704-709
[4]  
Bernstein CN, 2001, THROMB HAEMOSTASIS, V85, P430
[5]   Hyperhomocysteinemia, low folate and vitamin B12 concentrations, and methylene tetrahydrofolate reductase mutation in cerebral venous thrombosis [J].
Cantu, C ;
Alonso, E ;
Jara, A ;
Martínez, L ;
Ríos, C ;
Fernández, MDA ;
Garcia, I ;
Barinagarrementeria, F .
STROKE, 2004, 35 (08) :1790-1794
[6]  
Cattaneo M, 1998, THROMB HAEMOSTASIS, V80, P542
[7]  
Chowers Y, 2000, AM J GASTROENTEROL, V95, P3498
[8]   PLATELET DYSFUNCTION - A NEW DIMENSION IN INFLAMMATORY BOWEL-DISEASE [J].
COLLINS, CE ;
RAMPTON, DS .
GUT, 1995, 36 (01) :5-8
[9]   PLATELETS CIRCULATE IN AN ACTIVATED STATE IN INFLAMMATORY BOWEL-DISEASE [J].
COLLINS, CE ;
CAHILL, MR ;
NEWLAND, AC ;
RAMPTON, DS .
GASTROENTEROLOGY, 1994, 106 (04) :840-845
[10]   Homocysteine triggers mucosal microvascular activation in inflammatory bowel disease [J].
Danese, S ;
Sgambato, A ;
Papa, A ;
Scaldaferri, F ;
Pola, R ;
Sans, M ;
Lovecchio, M ;
Gasbarrini, G ;
Cittadini, A ;
Gasbarrini, A .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2005, 100 (04) :886-895