LIM domain proteins in cell mechanobiology

被引：33

作者：

Anderson, Caitlin A. ^{[1
]}

Kovar, David R. ^{[1
,2
]}

Gardel, Margaret L. ^{[3
,4
,5
,6
]}

Winkelman, Jonathan D. ^{[3
]}

机构：

[1] Univ Chicago, Dept Mol Genet & Cell Biol, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Biochem & Mol Biol, Chicago, IL 60637 USA

[3] Univ Chicago, Inst Biophys Dynam, Chicago, IL 60637 USA

[4] Univ Chicago, James Franck Inst, Chicago, IL 60637 USA

[5] Univ Chicago, Dept Phys, Chicago, IL 60637 USA

[6] Univ Chicago, Pritzker Sch Mol Engn, Chicago, IL 60637 USA

来源：

CYTOSKELETON | 2021年 / 78卷 / 06期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

actin cytoskeleton; focal adhesions; LIM proteins; adherens junctions; ACTIN-FILAMENTS; STRESS FIBERS; F-ACTIN; EXTRACELLULAR-MATRIX; FOCAL ADHESIONS; BINDING; PAXILLIN; FORCE; ZYXIN; AJUBA;

D O I：

10.1002/cm.21677

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The actin cytoskeleton is important for maintaining mechanical homeostasis in adherent cells, largely through its regulation of adhesion and cortical tension. The LIM (Lin-11, Isl1, MEC-3) domain-containing proteins are involved in a myriad of cellular mechanosensitive pathways. Recent work has discovered that LIM domains bind to mechanically stressed actin filaments, suggesting a novel and widely conserved mechanism of mechanosensing. This review summarizes the current state of knowledge of LIM protein mechanosensitivity.

引用

页码：303 / 311

页数：9

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