Effect of amphotericin B on the infection success of Schistosoma mansoni in Biomphalaria glabrata

被引：12

作者：

Mone, Yves ^{[1
]}

Mitta, Guillaume ^{[1
]}

Duval, David ^{[1
]}

Gourbal, Benjamin E. F. ^{[1
]}

机构：

[1] Univ Perpignan, UMR 5244, CNRS, EPHE,UPVD, F-66860 Perpignan, France

来源：

EXPERIMENTAL PARASITOLOGY | 2010年 / 125卷 / 02期

关键词：

Amphotericin B; Schistosoma mansoni; Miracidium; Biomphalaria glabrata; Reactive oxygen species (ROS); COMPATIBILITY POLYMORPHISM; MOLECULAR DETERMINANTS; ECHINOSTOMA-CAPRONI; LYMNAEA-STAGNALIS; HEMOCYTES; SPOROCYSTS; RESISTANCE; VITRO; HOST; INVOLVEMENT;

D O I：

10.1016/j.exppara.2009.12.024

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

In the present study, we examined the effect of amphotericin B on larval stages (miracidia and primary sporocyst) of the helminth Schistosoma mansoni, the causative agent of human schistosomiasis. Amphotericin B (AmB) is a polyene macrolide that disturbs the function of the cell membrane; it is widely used as prophylactic antimycotic agent in in vitro culture. We show for the first time that S. mansoni miracidia infectivity is considerably reduced after AmB treatment. Moreover we demonstrate that AmB does not affect the development, growth, viability, and behavior of miracidia and primary sporocysts. Our data indicate that AmB effects on S. mansoni sporocyst prevalence are linked to the oxidative properties of AmB. These may alter the capacity of sporocysts to respond to the oxidative stress generated by the snail immune defence system. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：70 / 75

页数：6

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