Influence of carrier particle size, carrier ratio and addition of fine ternary particles on the dry powder inhalation performance of insulin-loaded PLGA microcapsules

被引：31

作者：

Hamishehkar, Hamed ^{[2
]}

Emami, Jaber ^{[3
,4
]}

Najafabadi, Abdolhossien Rouholamini ^{[5
]}

Gilani, Kambiz ^{[5
]}

Minaiyan, Mohsen ^{[3
,4
]}

Mandavi, Hamid ^{[6
]}

Nokhodchi, Ali ^{[1
,7
]}

机构：

[1] Univ Kent, Medway Sch Pharm, Chatham ME4 4TB, Kent, England

[2] Tabriz Univ Med Sci, Drug Appl Res Ctr, Pharmaceut Technol Lab, Tabriz, Iran

[3] Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Esfahan, Iran

[4] Isfahan Univ Med Sci, Isfahan Pharmaceut Res Ctr, Esfahan, Iran

[5] Univ Tehran Med Sci, Sch Pharm, Aerosol Res Lab, Tehran, Iran

[6] Iran Polymer & Petrochem Inst, Dept Novel Drug Delivery Syst, Tehran, Iran

[7] Univ Greenwich, Medway Sch Pharm, Chatham ME4 4TB, Kent, England

来源：

POWDER TECHNOLOGY | 2010年 / 201卷 / 03期

关键词：

Dry powder inhalation; Carrier; Mannitol; Leucine; Insulin; PLGA microcapsules; LACTOSE CARRIER; DRUG-DELIVERY; SALBUTAMOL SULFATE; RESPIRATORY-TRACT; ADHESIVE MIXTURES; DEPOSITION; INHALERS; PARAMETERS; MORPHOLOGY; DISPERSION;

D O I：

10.1016/j.powtec.2010.04.017

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

The effects of carrier particle size, carrier ratio and addition of fine ternary agents on dry powder inhalation performance of insulin-loaded PLGA microcapsules were investigated. The use of mannitol with larger particle size in the lower carrier/microcapsules ratio led to higher deposition profiles of the drug. The fine spray dried mannitol and spray dried leucine as the ternary agents both decreased the deposition and dispersibility of microcapsules. It was concluded that addition of ternary component does not always improve aerosolization properties of DPI formulations. Carrier particle size, its flowability and carrier-drug ratio were shown to play an important role in DPI formulations. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：289 / 295

页数：7

共 37 条

[1] ABDELBARY A, 2007, ARCH PHARM RES, V30, P785
[2] [Anonymous], 1989, A Random Walk Through Fractal Dimensions, DOI 10.1002/9783527615995
[3] Ashurst I, 2000, Pharm Sci Technol Today, V3, P246, DOI 10.1016/S1461-5347(00)00275-3
[4] AUGSBURGER LL, 1974, SPROWLS AM PHARM INT, P301
[5] Beilmann B, 2007, AAPS PHARMSCITECH, V8
[6] Immobilization of fine particles on lactose carrier by precision coating and its effect on the performance of dry powder formulations
Chan, LW
Lim, LT
Heng, PWS
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 2003, 92 (05) : 975 - 984
[7] Carrier-based strategies for targeting protein and peptide drugs to the lungs
Cryan, SA
[J]. AAPS JOURNAL, 2005, 7 (01) : E20 - E41
[8] Air classifier technology (ACT) in dry powder inhalation Part II. The effect of lactose carrier surface properties on the drug-to-carrier interaction in adhesive mixtures for inhalation
de Boer, AH
Hagedoorn, P
Gjaltema, D
Goede, J
Kussendrager, KD
Frijlink, HW
[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2003, 260 (02) : 201 - 216
[9] A critical evaluation of the relevant parameters for drug redispersion from adhesive mixtures during inhalation
de Boer, AH
Dickhoff, BHJ
Hagedoorn, P
Gjaltema, D
Goede, J
Lambregts, D
Frijlink, HW
[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2005, 294 (1-2) : 173 - 184
[10] Particle size design of PLGA microspheres for potential pulmonary drug delivery using response surface methodology
Emami, Jaber
Hamishehkar, Hamed
Najafabadi, Abdolhossien Rouholamini
Gilani, Kambiz
Minaiyan, Mohsen
Mahdavi, Hamid
Mirzadeh, Hamid
Fakhari, Amir
Nokhodchi, Ali
[J]. JOURNAL OF MICROENCAPSULATION, 2009, 26 (01) : 1 - 8

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