Solitary fibrous tumor of soft tissue: a case report and immunohistochemical study

被引：6

作者：

Yuri, Takashi ^{[1
]}

Kanematsu, Sayaka ^{[1
]}

Lei, Yen-Chang ^{[1
]}

Kuwata, Maki ^{[1
]}

Oishi, Masaharu ^{[2
]}

Tsubura, Airo ^{[1
]}

机构：

[1] Kansai Med Univ, Dept Pathol 2, Osaka, Japan

[2] Kansai Med Univ, Takii Hosp, Div Surg, Osaka, Japan

来源：

MEDICAL MOLECULAR MORPHOLOGY | 2010年 / 43卷 / 01期

关键词：

Solitary fibrous tumor; Soft tissue; CD34; CD99; IGF-II; PDGFR; Immunohistochemistry; GROWTH-FACTOR-II; BETA-CATENIN; HYPOGLYCEMIA; HEMANGIOPERICYTOMA; PLEURA; CELLS; EXPRESSION; IMATINIB; SARCOMA;

D O I：

10.1007/s00795-009-0451-1

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A case of solitary fibrous tumor (SFT) arising in the soft tissue of the left inguinal region is reported. A 57-year-old Japanese woman presented with a nonadherent, well-defined, oval mass that was 2 x 3 cm in diameter and located in the inguinal soft tissue. Microscopic evaluation showed proliferation of spindle-shaped, fibroblast-like cells by the coexistence of hypo- and hypercellular areas with mast cell infiltration separated by hemangiopericytoma-like blood vessels. Immunohistochemistry revealed strong expression of CD34 and CD99 in the fibroblast-like cells, supporting the diagnosis of SFT. Although the patient was free of symptoms such as hypoglycemia, immunoreactive insulin-like growth factor (IGF)-II was localized in the socalled Golgi area of the spindle-shaped cells. In conclusion, immunoreactive IGF-II was detected in SFT that was not associated with hypoglycemia.

引用

页码：60 / 64

页数：5

共 29 条

[1] Andino L, 2006, ARCH PATHOL LAB MED, V130, P1503
[2] BRISELLI M, 1981, CANCER-AM CANCER SOC, V47, P2678, DOI 10.1002/1097-0142(19810601)47:11<2678::AID-CNCR2820471126>3.0.CO
[3] 2-9
[4] Solitary fibrous tumor associated with hypoglycemia: An example of the Doege-Potter syndrome
Chamberlain, MH
Taggart, DP
[J]. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2000, 119 (01) : 185 - 187
[5] Clinicopathological findings in a case series of extrathoracic solitary fibrous tumors of soft tissues
Daigeler A.
Lehnhardt M.
Langer S.
Steinstraesser L.
Steinau H.-U.
Mentzel T.
Kuhnen C.
[J]. BMC Surgery, 6 (1)
[6] Non-islet cell tumour-induced hypoglycaemia: a review of the literature including two new cases
De Groot, Jan Willem B.
Rikhof, Bart
Van Doom, Jaap
Bilo, Henk J. G.
Alleman, Maarten A.
Honkoop, Aafke H.
Van der Graaf, Winette T. A.
[J]. ENDOCRINE-RELATED CANCER, 2007, 14 (04) : 979 - 993
[7] Brief report:: Activity of imatinib in a patient with platelet-derived-growth-factor receptor positive malignant solitary fibrous tumor of the pleura
De Pas, Tommaso
Toffalorio, Francesca
Colombo, Piergiuseppe
Trifiro, Giuseppe
Pelosi, Giuseppe
Della Vigna, Paolo
Manzotti, Michela
Agostini, Monica
de Braud, Filippo
[J]. JOURNAL OF THORACIC ONCOLOGY, 2008, 3 (08) : 938 - 941
[8] LOCALIZED BENIGN AND MALIGNANT FIBROUS TUMORS OF THE PLEURA - A CLINICOPATHOLOGIC REVIEW OF 223 CASES
ENGLAND, DM
HOCHHOLZER, L
MCCARTHY, MJ
[J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1989, 13 (08) : 640 - 658
[9] Solitary fibrous tumour and haemangiopericytoma: evolution of a concept
Gengler, C
Guillou, L
[J]. HISTOPATHOLOGY, 2006, 48 (01) : 63 - 74
[10] Guillou L., 2002, Pathology and genetics of tumours of soft tissues and bone, P86

← 1 2 3 →