Comparative study of proton and phosphorus magnetic resonance spectroscopy in schizophrenia at 4 Tesla

被引：15
作者：
Théberge, J
Al-Semaan, Y
Jensen, JE
Williamson, PC
Neufeld, RWJ
Menon, RS
Schaefer, B
Densmore, M
Drost, DJ
机构：
[1] London Hlth Sci Ctr, Dept Psychiat, London, ON N6A 5A5, Canada
[2] Univ Western Ontario, Dept Med Biophys, London, ON, Canada
[3] King Faisal Specialist Hosp & Res Ctr, Riyadh, Saudi Arabia
[4] Harvard Univ, McLean Hosp, Dept Psychiat, Brain Imaging Ctr,Med Sch, Belmont, MA 02178 USA
[5] Univ Western Ontario, Dept Psychol, London, ON, Canada
[6] Robarts Res Inst, London, ON N6A 5C1, Canada
来源：
PSYCHIATRY RESEARCH-NEUROIMAGING | 2004年 / 132卷 / 01期
基金：
加拿大健康研究院;
关键词：
schizophrenia; spectroscopy; phosphorus; proton; phospholipid metabolism; high field; neurodegeneration;
D O I：
10.1016/j.pscychresns.2004.08.001
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
This study used high-field magnetic resonance spectroscopy to examine the correlation of 1H and 31P metabolite levels in patients with schizophrenia and normal controls. 1H and 31P in vivo spectra were acquired successively from the left anterior cingulate and left thalamus of nine chronic schizophrenic patients and eight comparable healthy controls. A significant positive correlation between glutamine (Gln) and phosphoethanolamine (PEtn) was found in the left anterior cingulate of patients. In the left thalamus of patients, a significant negative correlation between N-acetylaspartate (NAA) and glycerophosphocholine (GroPCho) was found. No significant correlations were found in controls. The correlation between glutamine and phosphoethanolamine may reflect a link between neurotransmission alterations and membrane phospholipid metabolism alterations. The negative correlation between N-acetylaspartate and glycerophosphocholine may reflect the presence of neurodegeneration. © 2004 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：33 / 39
页数：7
相关论文
共 39 条
  • [1] ALEXANDER GE, 1990, PROG BRAIN RES, V85, P119
  • [2] Andersen N., 1984, The Scale for the Assessment of Positive Symptoms (SAPS)
  • [3] ANDERSEN N, 1984, SCALE ASSESSMENT NEG
  • [4] PROTON MAGNETIC-RESONANCE SPECTROSCOPY OF HUMAN BRAIN INVIVO IN THE EVALUATION OF MULTIPLE-SCLEROSIS - ASSESSMENT OF THE LOAD OF DISEASE
    ARNOLD, DL
    MATTHEWS, PM
    FRANCIS, G
    ANTEL, J
    [J]. MAGNETIC RESONANCE IN MEDICINE, 1990, 14 (01) : 154 - 159
  • [5] Bartha R, 1999, NMR BIOMED, V12, P205, DOI 10.1002/(SICI)1099-1492(199906)12:4<205::AID-NBM558>3.0.CO
  • [6] 2-1
  • [7] Bartha R, 2000, MAGNET RESON MED, V44, P185, DOI 10.1002/1522-2594(200008)44:2<185::AID-MRM4>3.0.CO
  • [8] 2-V
  • [9] Bartha R, 1997, ARCH GEN PSYCHIAT, V54, P959
  • [10] Magnetic resonance spectroscopy - Bridging the neurochemistry and neuroanatomy of schizophrenia
    Buckley, PF
    Friedman, L
    [J]. BRITISH JOURNAL OF PSYCHIATRY, 2000, 176 : 203 - 205
1234