Two new dimeric abietane-type diterpenoids from the bark of Cryptomeria japonica and their enzyme inhibitory activity

被引：5

作者：

Chang, Chi-, I ^{[1
,2
]}

Cheng, Ming-Jen ^{[3
]}

Wang, Sheng-Yang ^{[4
,5
]}

Chen, Jih-Jung ^{[6
,7
]}

Wu, Ming-Der ^{[3
]}

Chen, Cheng-Chi ^{[8
]}

Ko, Horng-Huey ^{[9
]}

Kuo, Yueh-Hsiung ^{[10
,11
,12
]}

机构：

[1] Natl Pingtung Univ Sci & Technol, Dept Biol Sci & Technol, Pingtung 912, Taiwan

[2] Natl Pingtung Univ Sci & Technol, Res Ctr Act Nat Prod Dev, Pingtung 912, Taiwan

[3] FIRDI, BCRC, Hsinchu 300, Taiwan

[4] Natl Chung Hsing Univ, Dept Forestry, Taichung 402, Taiwan

[5] Acad Sinica, Agr Biotechnol Res Ctr, Taipei 115, Taiwan

[6] Natl Yang Ming Univ, Fac Pharm, Sch Pharmaceut Sci, Taipei 112, Taiwan

[7] China Med Univ Hosp, Dept Med Res, Taichung 404, Taiwan

[8] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan

[9] Kaohsiung Med Univ, Dept Fragrance & Cosmet Sci, Kaohsiung 807, Taiwan

[10] China Med Univ, Dept Chinese Pharmaceut Sci & Chinese Med Resourc, 91 Hsueh Shih Rd, Taichung 404, Taiwan

[11] Asia Univ, Dept Biotechnol, Taichung 413, Taiwan

[12] China Med Univ, Chinese Med Res Ctr, Taichung 404, Taiwan

来源：

PHYTOCHEMISTRY LETTERS | 2019年 / 33卷

关键词：

Cupressaceae; Cryptomeria japonica; Bark; Abietane; ANGIOTENSIN-CONVERTING ENZYME; XANTHINE-OXIDASE; JAPANESE CEDAR; HEARTWOOD; CONSTITUENTS; ANTIFEEDANTS; TERPENOIDS; EXTRACTS; QUINONE; OIL;

D O I：

10.1016/j.phytol.2019.08.001

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new dimeric abietane-type diterpenoids, 12-hydroxyabieta-8,11,13-trien-7 alpha-yl 7 beta-hydroxyisopimara-8(14), 15-diene-18-peroxoate (trivial name japonicinol A, 1) and 6 alpha, 7 alpha-O-(7,8-secoabieta-9(11), 13-diene-8,12-dioxo-7-ylidene) ferruginol (trivial name japonicinol B, 3), together with three known dimeric abietane-type diterpenoids, sugikurojin J (2), sugikurojin B (4) and formosaninol (5), were isolated from the bark of Cryptomeria japonica D. Don. Structure elucidation was accomplished by spectroscopic methods, mainly 1D and 2D NMR and HREIMS, as well as by comparison of their NMR data with those of related known analogues. At the concentration of 50 mu M, compounds 1-5 inhibited xanthine oxidase activity by 31.3, 23.4, 18.7, 17.3 and 24.4%, respectively. In addition, compound 4 also inhibited angiotensin-converting enzyme (ACE) activity by 19.2%.

引用

页码：84 / 89

页数：6

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