The effect of emotional stress on the primary humoral immunity of rats

被引：30

作者：

Shao, F

Lin, WJ ^{[1
]}

Wang, WW

Washington, WC

Zheng, L

机构：

[1] Chinese Acad Sci, Inst Psychol, Brain Behav Res Ctr, Beijing 100101, Peoples R China

[2] Peking Univ, Dept Psychol, Beijing, Peoples R China

来源：

JOURNAL OF PSYCHOPHARMACOLOGY | 2003年 / 17卷 / 02期

关键词：

antibody; emotional stress; empty water bottles; immunomodulation; sympathetic nervous system;

D O I：

10.1177/0269881103017002005

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The effect of exposure to emotional stress on humoral immune function after injection with ovalbumin, a novel antigen, was studied in adult male Wistar rats. Emotional stress was induced by randomly giving empty water bottles to rats trained to drink water at set times. The results showed that emotional stress induced the decrease in spleen weight and specific immunoglobulin G antibody level to ovalbumin, and increased levels of epinephrine, norepinephrine and corticosterone. A decrease of antibody levels correlated negatively with an increase in plasma norepinephrine levels. These findings suggest that emotional stress can modulate immune function, and that sympathetic nervous system may be involved in this immunomodulation.

引用

页码：179 / 183

页数：5

共 21 条

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