Short latency visual evoked potentials in occupational exposure to organic solvents

Objectives. Short latency visual evoked potentials (SVEP). in response to high-intensity flashes from light emitting diodes (LED). were used to detect subclinical effects along the visual pathway in four groups of subjects with different levels of exposure to gasoline. all within legally acceptable limits. Methods. Potentials and exposure levels were obtained from 31 subjects with different occupational exposure levels to gasoline fumes. as well as from 17 non-exposed control subjects. SVEP were recorded from four electrode sites (infra-orbital. C-z, P-z, O-z). in response to flashes presented to each eye in turn from goggle-mounted LEDs. SVEP components were defined after digital filtering. which eliminated the high-frequency oscillatory potentials and accentuated five major components: a periocular P-30, attributed to the retina: a fronto-central N-50, attributed to the optic nerve. centro-parietal P-65 and N-85, attributed to the optic tracts and radiation: and an occipital. cortical P-105. Results. The latencies of successive SVEP components of the exposed subjects showed a significant latency prolongation compared to controls. beginning with activity attributed to the optic nerve and increasing cumulatively with the later components. Retinal components were not affected by the exposure to organic solvents. Among the exposed groups. differences in latency prolongation corresponded to occupational exposure. Conclusion. The low-frequency components of SVEP were reliably measured and proved to be sensitive to subclinical effects of organic solvents on conduction along the visual pathway. These components are likely to be sensitive to other subcortical visual pathway lesions. but their clinical promise needs further verification. (C) 2000 Editions scientifiques et medicales Elsevier SAS.