Microfluidics-mediated assembly of functional nanoparticles for cancer-related pharmaceutical applications

被引：106
作者：
Feng, Qiang
Sun, Jiashu [1 ]
Jiang, Xingyu [1 ]
机构：
[1] Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China
来源：
NANOSCALE | 2016年 / 8卷 / 25期
关键词：
POLYMER HYBRID NANOPARTICLES; AFFECTS CELLULAR UPTAKE; DRUG-DELIVERY SYSTEMS; TOP-DOWN APPROACH; INTRACELLULAR TRAFFICKING; ENHANCED PERMEABILITY; LIPID NANOPARTICLES; GOLD NANOPARTICLES; PARTICLE-SIZE; QUANTUM DOTS;
D O I：
10.1039/c5nr07964k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The controlled synthesis of functional nanoparticles with tunable structures and properties has been extensively investigated for cancer treatment and diagnosis. Among a variety of methods for fabrication of nanoparticles, microfluidics-based synthesis enables enhanced mixing and precise fluidic modulation inside microchannels, thus allowing for the flow-mediated production of nanoparticles in a controllable manner. This review focuses on recent advances of using microfluidic devices for the synthesis of drug-loaded nanoparticles with specific characteristics (such as size, composite, surface modification, structure and rigidity) for enhanced cancer treatment and diagnosis as well as to investigate the bio-nanoparticle interaction. The discussion on microfluidics-based synthesis may shed light on the rational design of functional nanoparticles for cancer-related pharmaceutical applications.
引用
收藏
页码：12430 / 12443
页数：14
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